Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids

被引：42

作者：

Bhargava, Nidhi ^{[1
]}

Singh, Sukhvinder P. ^{[2
]}

Sharma, Anupam ^{[3
]}

Sharma, Prince ^{[4
]}

Capalash, Neena ^{[1
]}

机构：

[1] Panjab Univ, Dept Biotechnol, Chandigarh 160014, India

[2] Cent Coast Primary Ind Ctr, NSW Dept Primary Ind, Gosford, NSW 2250, Australia

[3] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India

[4] Panjab Univ, Dept Microbiol, Chandigarh 160014, India

来源：

FUTURE MICROBIOLOGY | 2015年 / 10卷 / 12期

关键词：

Acinetobacter baumannii; biofilm; catalase; flavonoids; Glycyrrhiza glabra; motility; quorum sensing inhibition; superoxide dismutase; PSEUDOMONAS-AERUGINOSA; BIOFILM FORMATION; SIGNAL MOLECULES; INHIBITION; EXPRESSION; MOTILITY; GENES; PLANT; TARGET;

D O I：

10.2217/fmb.15.107

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. Methods & results: Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm formation and production of antioxidant enzymes. Mechanistically, F1 downregulated the expression of autoinducer synthase gene, abaI, and consequently reduced (92%) the production of 3-OH-C12-HSL as determined by ESI-MS. Q-TOF and Q-TRAP analyses suggested the presence of flavonoids viz. licoricone, glycyrin and glyzarin as the active ingredients. Conclusion: This is the first report on quorum quenching activity of G. glabra linked to its flavonoids that downregulated the expression of abaI and attenuated quorum sensing regulated virulence of A. baumannii.

引用

页码：1953 / 1968

页数：16

共 50 条

[1] Quorum sensing-mediated regulation of staphylococcal virulence and antibiotic resistance
Singh, Rachna
Ray, Pallab
FUTURE MICROBIOLOGY, 2014, 9 (05) : 669 - 681
[2] Pyocyanin Stimulates Quorum Sensing-Mediated Tolerance to Oxidative Stress and Increases Persister Cell Populations in Acinetobacter baumannii
Bhargava, Nidhi
Sharma, Prince
Capalash, Neena
INFECTION AND IMMUNITY, 2014, 82 (08) : 3417 - 3425
[3] AbaM Regulates Quorum Sensing, Biofilm Formation, and Virulence in Acinetobacter baumannii
Lopez-Martin, Mario
Dubern, Jean-Frederic
Alexander, Morgan R.
Williams, Paul
JOURNAL OF BACTERIOLOGY, 2021, 203 (08)
[4] Attenuation of quorum sensing-mediated virulence in Gram-negative pathogenic bacteria: implications for the post-antibiotic era
Singh, Ravindra Pal
MEDCHEMCOMM, 2015, 6 (02) : 259 - 272
[5] Ketoprofen, piroxicam and indomethacin-suppressed quorum sensing and virulence factors in Acinetobacter baumannii
Elshaer, Soha Lotfy
Shaldam, Moataz A.
Shaaban, Mona, I
JOURNAL OF APPLIED MICROBIOLOGY, 2022, 133 (04) : 2182 - 2197
[6] Streptomycin Inhibits Quorum Sensing in Acinetobacter baumannii
Saroj, Sunil D.
Rather, Philip N.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (04) : 1926 - 1929
[7] Effect of the synthetic cannabinoid HU-210 on quorum sensing and on the production of quorum sensing-mediated virulence factors by Vibrio harveyi
Divya Soni
Reem Smoum
Aviva Breuer
Raphael Mechoulam
Doron Steinberg
BMC Microbiology, 15
[8] Effect of the synthetic cannabinoid HU-210 on quorum sensing and on the production of quorum sensing-mediated virulence factors by Vibrio harveyi
Soni, Divya
Smoum, Reem
Breuer, Aviva
Mechoulam, Raphael
Steinberg, Doron
BMC MICROBIOLOGY, 2015, 15
[9] Inhibition of quorum sensing-mediated virulence in Serratia marcescens by Bacillus subtilis R-18
Devi, Kannan Rama
Srinivasan, Subramaniyan
Ravi, Arumugam Veera
MICROBIAL PATHOGENESIS, 2018, 120 : 166 - 175
[10] Contribution of the AbaI/AbaR Quorum Sensing System to Resistance and Virulence of Acinetobacter baumannii Clinical Strains
Tang, Jie
Chen, Yan
Wang, Xinlei
Ding, Yue
Sun, Xiaoyu
Ni, Zhaohui
INFECTION AND DRUG RESISTANCE, 2020, 13 : 4273 - 4281

← 1 2 3 4 5 →