Proteasome-mediated quality control of S-nitrosylated mitochondrial proteins

被引：11

作者：

Benischke, Anne-Sophie ^{[1
]}

Hemion, Charles ^{[1
]}

Flammer, Josef ^{[2
]}

Neutzner, Albert ^{[1
,2
]}

机构：

[1] Univ Basel, Dept Biomed, Basel, Switzerland

[2] Univ Basel, Dept Ophthalmol, Basel, Switzerland

来源：

MITOCHONDRION | 2014年 / 17卷

基金：

瑞士国家科学基金会;

关键词：

Mitochondria; Proteasome; Ubiquitin; p97; S-nitrosylation; DEGRADATION; NEURODEGENERATION; MECHANISMS; PARKIN; P97;

D O I：

10.1016/j.mito.2014.04.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accumulating low level mitochondrial insults are thought to be key to aging processes and neurodegeneration. Among other stressors, protein damage due to nitrosative stress negatively impacts mitochondrial function and is linked to neurodegeneration. Using biotin switch technique, we show that mitochondrial proteins are S-nitrosylated not only in the presence but also in the absence of exogenous nitrosative stress. In addition, we revealed a role for the ubiquitin-proteasome system and the outer mitochondrial membrane associated degradation (OMMAD)-component p97 in the quality control of S-nitrosylated mitochondrial. Taken together, constant proteasome-mediated clearance of nitrosatively-damaged proteins from mitochondria is likely important for maintaining organelle function. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：182 / 186

页数：5

共 26 条

[1] S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation -: A novel antiapoptotic mechanism that suppresses apoptosis [J].