Quantitative analysis of foot-and-mouth disease virus RNA duration in tissues of experimentally infected pigs

被引：10

作者：

Zhang, Zhidong ^{[1
]}

Bashiruddin, John B. ^{[1
]}

机构：

[1] Inst Anim Hlth, Pirbright Lab, Surrey GU24 0NF, England

来源：

VETERINARY JOURNAL | 2009年 / 180卷 / 01期

关键词：

Foot-and-mouth disease; Foot-and-mouth disease virus; FMD; Real-time RT-PCR; Persistence; PATHOGENESIS; PERSISTENCE; SITE;

D O I：

10.1016/j.tvjl.2007.11.010

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Quantitative analysis of the duration of foot-and-mouth disease virus (FMDV) RNA in tissues was carried out in pigs experimentally infected with FMDV O UKG 34/2001 and O SKR 1/2000. The results showed that the viral RNA was still detectable in cervical lymph nodes, mandibular lymph nodes and tonsils collected froth both inoculated and contact pigs at 28 days post infection. There was no detectable viral RNA in the soft palate or pharynx, which are thought to be tissue sites for viral persistence in cattle. Further study is needed to clarify whether this difference has significance in terms of viral clearance in pigs. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：130 / 132

页数：3

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