The degradation of poly(trimethylene carbonate) implants: The role of molecular weight and enzymes

被引：56
作者：
Yang, Liqun [1 ,2 ,3 ]
Li, Jianxin [2 ,3 ]
Zhang, Wei [2 ,3 ]
Jin, Ying [2 ,3 ]
Zhang, Jinzhe [2 ,3 ]
Liu, Yan [2 ,3 ]
Yi, Dongxu [2 ,3 ]
Li, Miao [2 ,3 ]
Guo, Jing [2 ,3 ]
Gu, Zhongwei [1 ]
机构：
[1] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
[2] Natl Hlth & Family Planning Commiss, Key Lab Reprod Hlth & Med Genet, Shenyang 110031, Peoples R China
[3] Liaoning Res Inst Family Planning, Key Lab Reprod Hlth, Shenyang 110031, Peoples R China
来源：
POLYMER DEGRADATION AND STABILITY | 2015年 / 122卷
基金：
美国国家科学基金会;
关键词：
Poly(trimethylene carbonate); In vitro degradation; In vivo implantation; Molecular weight; Lipase; Form-stability; IN-VITRO DEGRADATION; TRIMETHYLENE CARBONATE; VIVO DEGRADATION; EPSILON-CAPROLACTONE; POLY(1,3-TRIMETHYLENE CARBONATE); 1,3-TRIMETHYLENE CARBONATE; BIODEGRADABLE POLYMERS; MECHANICAL-PROPERTIES; ENZYMATIC-HYDROLYSIS; NORPLANT IMPLANTS;
D O I：
10.1016/j.polymdegradstab.2015.10.016
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The degradation of poly(trimethylene carbonate) (PTMC) implants with different molecular weights was investigated in vitro and in vivo. The results showed that PTMC degraded in vitro enzymolysis case and in vivo via surface erosion. The effect of the molecular weight on the degradation rate of PTMC was investigated in light of hydrophilicity and form-stability. A higher degradation rate was seen in the high molecular weight PTMC and its more hydrophobic surface with better form-stability. Furthermore, PTMC had a higher degradation rate of in vitro enzymolysis because of the surfactants role of lipase in diffusion of the degradation products. The results indicate that the form-stabilized PTMC is a promising candidate for clinical subcutaneous implants especially due to their tunable degradation rate. (C) 2015 Elsevier Ltd. All rights reserved.
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收藏
页码：77 / 87
页数：11
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