Chemical Composition, Antioxidant, Anti-Inflammatory and Anti-Proliferative Activities of Essential Oils of Plants from Burkina Faso

被引：135

作者：

Bayala, Bagora ^{[1
,2
,3
,4
,5
]}

Bassole, Imael Henri Nestor ^{[6
]}

Gnoula, Charlemagne ^{[1
,7
]}

Nebie, Roger ^{[8
]}

Yonli, Albert ^{[1
]}

Morel, Laurent ^{[2
,3
,4
,5
]}

Figueredo, Gilles ^{[9
]}

Nikiema, Jean-Baptiste ^{[1
,10
]}

Lobaccaro, Jean-Marc A. ^{[2
,3
,4
,5
]}

Simpore, Jacques ^{[1
,10
]}

机构：

[1] Univ Ouagadougou, Ctr Med St Camille, Lab Biol & Genet LABIOGENE, Ctr Rech Biomol Pietro Annigoni CERBA, Ouagadougou, Burkina Faso

[2] Univ Clermont Ferrand 2, Univ Blaise Pascal, Clermont Ferrand, France

[3] CNRS, Unite Mixte Rech UMR 6293, GReD, Aubiere, France

[4] INSERM, UMR 1103, GReD, Aubiere, France

[5] Ctr Rech Nutr Humaine Auvergne, Clermont Ferrand, France

[6] Univ Ouagadougou, Lab Biochim Alimentaire Enzymol Biotechnol Ind &, Unite Format & Rech Sci Vie & Terre UFR SVT, Ouagadougou, Burkina Faso

[7] Univ Ouagadougou, Lab Pharmacol Toxicol & Chim Therapeut, Unite Format & Rech Sci Sante UFR SDS, Ouagadougou, Burkina Faso

[8] Inst Rech Sci Appl & Tech, Dept Subst Nat, Ouagadougou, Burkina Faso

[9] Biopole Clermont Limagne, LEXVA Analyt, St Beauzire, France

[10] Ctr Med St Camille Ouagadougou, Ouagadougou, Burkina Faso

来源：

PLOS ONE | 2014年 / 9卷 / 03期

关键词：

OCIMUM-BASILICUM L; HUMAN PROSTATIC-CARCINOMA; AGERATUM-CONYZOIDES L; IN-VITRO; ANTIMICROBIAL ACTIVITY; LARVICIDAL ACTIVITY; BIOLOGICAL-ACTIVITY; LIPPIA-MULTIFLORA; MEDICINAL-PLANTS; OXIDATIVE STRESS;

D O I：

10.1371/journal.pone.0092122

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This research highlights the chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils from leaves of Ocimum basilicum, Ocimum americanum, Hyptis spicigera, Lippia multiflora, Ageratum conyzoides, Eucalyptus camaldulensis and Zingiber officinale. Essential oils were analyzed by gas chromatography-mass spectrometry and gas chromatography-flame ionization detector. Major constituents were alpha-terpineol (59.78%) and beta-caryophyllene (10.54%) for Ocimum basilicum; 1, 8-cineol (31.22%), camphor (12.730%), alpha-pinene (6.87%) and trans alpha-bergamotene (5.32%) for Ocimum americanum; beta-caryophyllene (21%), alpha-pinene (20.11%), sabinene (10.26%), beta-pinene (9.22%) and alpha-phellandrene (7.03%) for Hyptis spicigera; p-cymene (25.27%), beta-caryophyllene (12.70%), thymol (11.88), gamma-terpinene (9.17%) and thymyle acetate (7.64%) for Lippia multiflora; precocene (82.10%) for Ageratum conyzoides; eucalyptol (59.55%), a-pinene (9.17%) and limonene (8.76%) for Eucalyptus camaldulensis; arcurcumene (16.67%), camphene (12.70%), zingiberene (8.40%), beta-bisabolene (7.83%) and beta-sesquiphellandrene (5.34%) for Zingiber officinale. Antioxidant activities were examined using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. O. basilicum and L. multiflora exhibited the highest antioxidant activity in DPPH and ABTS tests, respectively. Anti-inflammatory properties were evaluated by measuring the inhibition of lipoxygenase activity and essential oil of Z. officinale was the most active. Anti-proliferative effect was assayed by the measurement of MTT on LNCaP and PC-3 prostate cancer cell lines, and SF-763 and SF-767 glioblastoma cell lines. Essential oils from A. conyzoides and L. multiflora were the most active on LNCaP and PC-3 cell lines, respectively. The SF-767 glioblastoma cell line was the most sensitive to O. basilicum and L. multiflora EOs while essential oil of A. conyzoides showed the highest activity on SF-763 cells. Altogether these results justify the use of these plants in traditional medicine in Burkina Faso and open a new field of investigation in the characterization of the molecules involved in anti-proliferative processes.

引用

页数：11

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