MIF: Mood Improving/Inhibiting Factor?

被引：34
作者：
Bloom, Joshua [1 ,2 ]
Al-Abed, Yousef [2 ]
机构：
[1] Hofstra North Shore LIJ Sch Med, Hempstead, NY 11549 USA
[2] Feinstein Inst Med Res, Ctr Mol Innovat, Manhasset, NY 11030 USA
来源：
JOURNAL OF NEUROINFLAMMATION | 2014年 / 11卷
关键词：
MIF; Depression; Neuroinflammation; Neurogenesis; Antidepressant; Biomarker; MIGRATION INHIBITORY FACTOR; PROTEIN-KINASE MAPK; MAJOR DEPRESSION; RAT-BRAIN; GLUCOCORTICOID-RECEPTORS; GROWTH-FACTOR; CELL-CYCLE; EXPRESSION; STRESS; INFLAMMATION;
D O I：
10.1186/1742-2094-11-11
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiology. Inflammation and cytokines have emerged as a promising new avenue in depression research, and, in particular, macrophage migration inhibitory factor (MIF) has been shown to be significant in depression physiology. In this review we summarize current research on MIF and depression. We highlight the arguments for MIF as a pro-and antidepressant species and discuss the potential implications for therapeutics.
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页数：9
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