Intrauterine growth retardation:: Study of placental apoptosis

被引：0
作者：
Barrio, E
Calvo, MT
Romo, A
Alvarez, R
Gutiérrez, JI
Naval, J
Longás, AF
机构：
[1] Univ Zaragoza, Childrens Hosp Miguel Servet, Dept Mol Genet, E-50009 Zaragoza, Spain
[2] Univ Zaragoza, Childrens Hosp Miguel Servet, Dept Neonatol, E-50009 Zaragoza, Spain
[3] Univ Zaragoza, Childrens Hosp Miguel Servet, Dept Pathol Anat, E-50009 Zaragoza, Spain
[4] Univ Zaragoza, Childrens Hosp Miguel Servet, Dept Endocrinol, E-50009 Zaragoza, Spain
[5] Univ Zaragoza, Dept Biochem & Mol & Cellular Biol, E-50009 Zaragoza, Spain
来源：
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2004年 / 17卷
关键词：
intrauterine growth retardation; placental apoptosis; placental dysfunction;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We studied the rate of apoptosis in the placental tissue of pregnancies complicated with intrauterine growth retardation (IUGR) and compared it with the results obtained in normal placentas. Our results clearly demonstrate a strongly increased rate of apoptosis in placentas of children born with IUGR, suggesting severe placental dysfunction. The significance of these findings needs further study.
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收藏
页码：451 / 456
页数：6
相关论文
共 31 条
[1]   Placental apoptosis in preeclampsia [J].
Allaire, AD ;
Ballenger, KA ;
Wells, SR ;
McMahon, MJ ;
Lessey, BA .
OBSTETRICS AND GYNECOLOGY, 2000, 96 (02) :271-276
[2]  
Axt R., 1999, Clinical and Experimental Obstetrics and Gynecology, V26, P56
[3]  
BAKER J, 1993, CELL, V75, P73, DOI 10.1016/0092-8674(93)90680-O
[4]   FETAL NUTRITION AND CARDIOVASCULAR-DISEASE IN ADULT LIFE [J].
BARKER, DJP ;
GLUCKMAN, PD ;
GODFREY, KM ;
HARDING, JE ;
OWENS, JA ;
ROBINSON, JS .
LANCET, 1993, 341 (8850) :938-941
[5]  
Calvo MT, 2004, J PEDIATR ENDOCR MET, V17, P445
[6]  
CALVO MT, 2003, AN PEDIAT S2, V58, P45
[7]   Apoptotic and proliferative activities in first trimester placentae [J].
Chan, CCW ;
Lao, TT ;
Cheung, ANY .
PLACENTA, 1999, 20 (2-3) :223-227
[8]   Decreased expression of placental growth hormone in intrauterine growth retardation [J].
Chowen, JA ;
EvainBrion, D ;
Pozo, J ;
Alsat, E ;
GarciaSegura, LM ;
Argente, J .
PEDIATRIC RESEARCH, 1996, 39 (04) :736-739
[9]   Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction [J].
Crocker, IP ;
Cooper, S ;
Ong, SC ;
Baker, PN .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (02) :637-643
[10]  
DIHINX JG, 2002, THESIS U ZARAGOZA
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