Patient-reported outcomes in asthma clinical trials

被引:16
作者
Braido, Fulvio [1 ]
Baiardini, Ilaria [1 ]
Canonica, Giorgio W. [2 ]
机构
[1] Univ Hosp, IRCCS San Martino Genova, Dept Internal Med, I-16132 Genoa, Italy
[2] Humanitas Univ, Humanitas Clin & Res Ctr, Personalized Med Clin Asthma & Allergy, Dept Biomed Sci, Milan, Italy
关键词
asthma; asthma control; health status; patient-reported outcomes; quality of life; QUALITY-OF-LIFE; MILD-TO-MODERATE; RANDOMIZED-TRIALS; ALLERGIC-ASTHMA; CHRONIC COUGH; DOUBLE-BLIND; QUESTIONNAIRE; EFFICACY; ADULTS; VALIDATION;
D O I
10.1097/MCP.0000000000000440
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Purpose of review The review provides an overview of the results of asthma clinical trials published in peer review journals in the last 18 months that evaluated patient-reported outcomes (PROs). Recent findings In the last 10 years, health care moved toward a patient-centered approach, which includes patients' perspectives reflecting the impact of a disease and its treatment. Summary Surprisingly, among the almost 300 clinical trials published in the last one and a half year, PRO evaluation was performed in only 20 studies, and none of them held in a real-life setting. The effort of applying the scientific methods of PRO investigations in asthma clinical trials following a rigorous and systematic approach needs to be highly improved to allow better understanding of patient reported factors. Some recommendations are drawn particularly about PRO assessment in personalized medicine research. The ability of an individual PRO to evaluate choice of treatment and its effectiveness remains to be achieved.
引用
收藏
页码:70 / 77
页数:8
相关论文
共 65 条
[1]   Clinimetric evaluation of the Sinonasal Outcome Test-16 [J].
Anderson, ER ;
Murphy, MP ;
Weymuller, EA .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1999, 121 (06) :702-707
[2]  
[Anonymous], COPD
[3]  
[Anonymous], 2005, REFL PAP REG GUID US
[4]  
[Anonymous], PAT REP OUTC PROS PE
[5]  
[Anonymous], EHR INC PROGR 2015
[6]   Implementing patient-reported outcome measures in palliative care clinical practice: A systematic review of facilitators and barriers [J].
Antunes, Barbara ;
Harding, Richard ;
Higginson, Irene J. .
PALLIATIVE MEDICINE, 2014, 28 (02) :158-175
[7]   Rhinasthma: a new specific QoL questionnaire for patients with rhinitis and asthma [J].
Baiardini, I ;
Pasquali, M ;
Giardini, A ;
Specchia, C ;
Passalacqua, G ;
Venturi, S ;
Braido, F ;
Bonini, S ;
Majani, G ;
Canonica, GW .
ALLERGY, 2003, 58 (04) :289-294
[8]   A new tool to assess and monitor the burden of chronic cough on quality of life: Chronic Cough Impact Questionnaire [J].
Baiardini, I ;
Braido, F ;
Fassio, O ;
Tarantini, F ;
Pasquali, M ;
Tarchino, F ;
Berlendis, A ;
Canonica, GW .
ALLERGY, 2005, 60 (04) :482-488
[9]   Asthma health status measurement in clinical practice: validity of a new short and simple instrument [J].
Barley, EA ;
Quirk, FH ;
Jones, PW .
RESPIRATORY MEDICINE, 1998, 92 (10) :1207-1214
[10]   A new tool for monitoring asthma outcomes: The ITG asthma short form [J].
Bayliss, MS ;
Espindle, DM ;
Buchner, D ;
Blaiss, MS ;
Ware, JE .
QUALITY OF LIFE RESEARCH, 2000, 9 (04) :451-466