Polymorphisms in autophagy genes and active pulmonary tuberculosis susceptibility in Romania

被引：3

作者：

Cucu, Mihai Gabriel ^{[1
]}

Streata, Ioana ^{[1
]}

Riza, Anca Lelia ^{[1
]}

Cimpoeru, Alina Liliana ^{[1
]}

Serban-Sosoi, Simona ^{[1
]}

Ciocoiu, Adela ^{[1
]}

Plesea, Razvan Mihail ^{[1
]}

Popescu, Elena Leocadia ^{[1
]}

Dorobantu, Stefania ^{[1
]}

Anghel, Andreea ^{[1
]}

Stroe, Aida Maria ^{[1
]}

Stefan, Andreea Nicoleta ^{[1
]}

Cioboata, Ramona ^{[2
]}

Bazavan, Ileana ^{[2
]}

Ciontea, Marius Sorin ^{[3
]}

Capitanescu, Iulia ^{[3
]}

Olteanu, Mihai ^{[2
]}

Nitu, Mimi ^{[2
]}

Burada, Florin ^{[1
]}

Tataru, Tiberiu ^{[4
]}

Netea, Mihai ^{[5
,6
]}

van Crevel, Reinout ^{[5
,6
]}

Olaru, Marian ^{[2
]}

Mixich, Francisc ^{[1
]}

Ioana, Mihai ^{[1
]}

机构：

[1] Univ Med & Pharm Craiova, Craiova, Dolj County, Romania

[2] Victor Babes Infect Dis & Pneumophtisiol Hosp Cra, Craiova, Dolj County, Romania

[3] Tudor Vladimirescu Pneumophtisiol Hosp Runcu, Runcu, Gorj County, Romania

[4] Emergency Cty Hosp Targu Jiu, Targu Jiu, Romania

[5] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis RCI, Nijmegen, Netherlands

来源：

REVISTA ROMANA DE MEDICINA DE LABORATOR | 2017年 / 25卷 / 01期

关键词：

tuberculosis; gene polymorphism; autophagy; innate immune system; allele; CROHNS-DISEASE; NOD2; INFLAMMATION; ASSOCIATION; POPULATIONS; ADAPTATIONS; MACHINERY; INDUCTION; VARIANTS; IMMUNITY;

D O I：

10.1515/rrlm-2017-0002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Autophagy, a homeostatic process involved in nutrient regeneration and immune responses, may be involved in intracellular killing of M. tuberculosis. Several studies linked variation in autophagy genes with susceptibility to pulmonary tuberculosis, but others did not confirm these findings. We genotyped single nucleotide polymorphisms (SNPs) in the ATG5 (rs2245214, c.574-12777G>C) and NOD2 (rs2066844, c.2104C>T) genes for 256 pulmonary tuberculosis patients and 330 unrelated healthy controls in Romania. Both SNPs have been reported as relevant for the autophagy process and potentially for susceptibility to active pulmonary tuberculosis. In our study, the polymorphisms in ATG5 and NOD2 were not associated with tuberculosis. This suggests that the two genetic variants we focused on are not related to the risk for developing active TB in a Romanian population.

引用

页码：47 / 53

页数：7

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