New pyridine derivatives as potential antimicrobial agents

被引：76

作者：

Klimesová, V

Svoboda, M

Waisser, K

Pour, M

Kaustová, J

机构：

[1] Charles Univ Prague, Fac Pharm, Dept Inorgan & Organ Chem, Hradec Kralove 50005, Czech Republic

[2] Charles Univ Prague, Fac Pharm, Dept Inorgan & Organ Chem, Lab Struct & Interact Biol Act Mol, Hradec Kralove 50005, Czech Republic

[3] Reg Inst Hyg, Natl Reference Lab Mycobacterium Kansasii, Ostrava, Czech Republic

来源：

FARMACO | 1999年 / 54卷 / 10期

关键词：

pyridine; alkylthiopyridine; piperidylpyridine; antimycobacterial activity; antifungal activity;

D O I：

10.1016/S0014-827X(99)00078-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A set of pyridine derivatives bearing a substituted alkylthio chain or a piperidyl ring in position 2 or 4 were synthesized, and their antimycobacterial and antifugal activities were evaluated. Chemical structures were confirmed by IR and NMR data, and by elemental analysis. Minimum inhibitory concentrations (MIC) were used for the evaluation of microbiological activity in vitro. The compounds were moderately active against both Mycobacterium tuberculosis and nontuberculous mycobacteria. The most active compound was 2-cyanomethylthiopyridine-4-carbonitrile (7) with MTC against Mycobacterium kansasii in the range of 8-4 mu mol/l. The antifungal activities of the compounds were relatively low. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：666 / 672

页数：7

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