Ebola Virus RNA Stability in Human Blood and Urine in West Africa's Environmental Conditions

被引：10

作者：

Janvier, Frederic ^{[1
,2
]}

Delaune, Deborah ^{[2
,3
]}

Poyot, Thomas ^{[4
]}

Valade, Eric ^{[4
]}

Merens, Audrey ^{[3
]}

Rollin, Pierre E. ^{[5
]}

Foissaud, Vincent ^{[2
,6
]}

机构：

[1] Hop Instruct Armees St Anne, F-83800 Toulon, France

[2] Ctr Traitement Soignants, Conakry, Guinea

[3] Hop Instruct Armees Begin, St Mande, France

[4] Inst Rech Biomed Armees, Bretigny Sur Orge, France

[5] Ctr Dis Control & Prevent, Atlanta, GA USA

[6] Hop Instruct Armees Percy, Clamart, France

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 02期

关键词：

HEMORRHAGIC-FEVER; OUTBREAK; PCR; DIAGNOSIS; SURFACES;

D O I：

10.3201/eid2202.151395

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated RNA stability of Ebola virus in EDTA blood and urine samples collected from infected patients and stored in West Africa's environmental conditions. In blood, RNA was stable for at least 18 days when initial cycle threshold values were <30, but in urine, RNA degradation occurred more quickly.

引用

页码：292 / 294

页数：3

共 15 条

[1] Ebola Virus Stability on Surfaces and in Fluids in Simulated Outbreak Environments [J].

Fischer, Robert ;

Judson, Seth ;

Miazgowicz, Kerri ;

Bushmaker, Trenton ;

Prescott, Joseph ;

Munster, Vincent J. .

EMERGING INFECTIOUS DISEASES, 2015, 21 (07) :1243-1246

[2] The Use of a Mobile Laboratory Unit in Support of Patient Management and Epidemiological Surveillance during the 2005 Marburg Outbreak in Angola [J].

Grolla, Allen ;

Jones, Steven M. ;

Fernando, Lisa ;

Strong, James E. ;

Stroeher, Ute ;

Moeller, Peggy ;

Paweska, Janusz T. ;

Burt, Felicity ;

Pablo Palma, Pedro ;

Sprecher, Armand ;

Formenty, Pierre ;

Roth, Cathy ;

Feldmann, Heinz .

PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (05)

[3] Clinical presentation, biochemical, and haematological parameters and their association with outcome in patients with Ebola virus disease: an observational cohort study [J].

Hunt, Luke ;

Gupta-Wright, Ankur ;

Simms, Victoria ;

Tamba, Fayia ;

Knott, Victoria ;

Tamba, Kongoneh ;

Heisenberg-Mansaray, Saidu ;

Tamba, Emmanuel ;

Sheriff, Alpha ;

Conteh, Sulaiman ;

Smith, Tom ;

Tobin, Shelagh ;

Brooks, Tim ;

Houlihan, Catherine ;

Cummings, Rachael ;

Fletcher, Tom .

LANCET INFECTIOUS DISEASES, 2015, 15 (11) :1292-1299

[4]

Janvier F, 2015, J INFECT DI IN PRESS

[5] Difficulties of interpretation of Zaire Ebola Virus PCR results and implication in the field [J].

Janvier, Frederic ;

Gorbatch, Sophie ;

Queval, Lucie ;

Top, Julie ;

Vigier, Cecile ;

Cotte, Jean ;

Foissaud, Vincent .

JOURNAL OF CLINICAL VIROLOGY, 2015, 67 :36-37

[6] A Case of Severe Ebola Virus Infection Complicated by Gram-Negative Septicemia [J].

Kreuels, Benno ;

Wichmann, Dominic ;

Emmerich, Petra ;

Schmidt-Chanasit, Jonas ;

de Heer, Geraldine ;

Kluge, Stefan ;

Sow, Abdourahmane ;

Renne, Thomas ;

Guenther, Stephan ;

Lohse, Ansgar W. ;

Addo, Marylyn M. ;

Schmiedel, Stefan .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (25) :2394-2401

[7]

Leroy EM, 2000, J MED VIROL, V60, P463, DOI 10.1002/(SICI)1096-9071(200004)60:4<463::AID-JMV15>3.0.CO

[8]

2-M

[9] Clinical Care of Two Patients with Ebola Virus Disease in the United States [J].

Lyon, G. Marshall ;

Mehta, Aneesh K. ;

Varkey, Jay B. ;

Brantly, Kent ;

Plyler, Lance ;

McElroy, Anita K. ;

Kraft, Colleen S. ;

Towner, Jonathan S. ;

Spiropoulou, Christina ;

Stroeher, Ute ;

Uyeki, Timothy M. ;

Ribner, Bruce S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (25) :2402-2409

[10] Postmortem Stability of Ebola Virus [J].

Prescott, Joseph ;

Bushmaker, Trenton ;

Fischer, Robert ;

Miazgowicz, Kerri ;

Judson, Seth ;

Munster, Vincent J. .

EMERGING INFECTIOUS DISEASES, 2015, 21 (05) :856-859

← 1 2 →