Next-generation characterization of the Cancer Cell Line Encyclopedia

被引：2142

作者：

Ghandi, Mahmoud ^{[1
]}

Huang, Franklin W. ^{[1
,2
,14
]}

Jane-Valbuena, Judit ^{[1
,2
]}

Kryukov, Gregory V. ^{[1
]}

Lo, Christopher C. ^{[1
]}

McDonald, E. Robert, III ^{[3
]}

Barretina, Jordi ^{[3
,16
]}

Gelfand, Ellen T. ^{[1
]}

Bielski, Craig M. ^{[1
]}

Li, Haoxin ^{[1
,2
]}

Hu, Kevin ^{[1
]}

Andreev-Drakhlin, Alexander Y. ^{[1
]}

Kim, Jaegil ^{[1
]}

Hess, Julian M. ^{[1
]}

Haas, Brian J. ^{[1
]}

Aguet, Francois ^{[1
]}

Weir, Barbara A. ^{[1
]}

Rothberg, Michael V. ^{[1
]}

Paolella, Brenton R. ^{[1
]}

Lawrence, Michael S. ^{[1
,4
,5
,6
]}

Akbani, Rehan ^{[7
]}

Lu, Yiling ^{[7
]}

Tiv, Hong L. ^{[8
]}

Gokhale, Prafulla C. ^{[8
]}

De Weck, Antoine ^{[9
]}

Mansour, Ali Amin ^{[1
]}

Oh, Coyin ^{[1
]}

Shih, Juliann ^{[1
]}

Hadi, Kevin ^{[10
,11
,12
]}

Rosen, Yanay ^{[1
]}

Bistline, Jonathan ^{[1
]}

Venkatesan, Kavitha ^{[3
]}

Reddy, Anupama ^{[3
]}

Sonkin, Dmitriy ^{[3
,15
]}

Liu, Manway ^{[3
]}

Lehar, Joseph ^{[3
]}

Korn, Joshua M. ^{[3
]}

Porter, Dale A. ^{[3
]}

Jones, Michael D. ^{[3
]}

Golji, Javad ^{[3
]}

Caponigro, Giordano ^{[3
]}

Taylor, Jordan E. ^{[1
]}

Dunning, Caitlin M. ^{[1
]}

Creech, Amanda L. ^{[1
]}

Warren, Allison C. ^{[1
]}

McFarland, James M. ^{[1
]}

Zamanighomi, Mahdi ^{[1
]}

Kauffmann, Audrey ^{[9
]}

Stransky, Nicolas ^{[1
]}

Imielinski, Marcin ^{[10
,11
,12
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[3] Novartis Inst Biomed Res, Cambridge, MA 02139 USA

[4] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA

[5] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[6] Harvard Med Sch, Boston, MA 02115 USA

[7] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[8] Belfer Ctr Appl Canc Sci, Boston, MA USA

[9] Novartis Inst Biomed Res, Basel, Switzerland

[10] New York Genome Ctr, New York, NY USA

[11] Weill Cornell Med, Inst Computat Biomed, Englander Inst Precis Med, Dept Pathol & Lab Med, New York, NY USA

[12] Weill Cornell Med, Meyer Canc Ctr, New York, NY USA

[13] Howard Hughes Med Inst, Chevy Chase, MD USA

[14] Univ Calif San Francisco, San Francisco, CA 94143 USA

[15] NCI, Rockville, MD USA

[16] Girona Biomed Res Inst IDIBGI, Girona, Spain

来源：

NATURE | 2019年 / 569卷 / 7757期

关键词：

MISMATCH REPAIR DEFICIENCY; DNA METHYLATION; PROTEIN; MUTATIONS; RNA; CONSISTENCY; RESISTANCE; LANDSCAPE; MDM4; MAP;

D O I：

10.1038/s41586-019-1186-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological therapeutics and to identify new marker-driven cancer dependencies. To improve our understanding of the molecular features that contribute to cancer phenotypes, including drug responses, here we have expanded the characterizations of cancer cell lines to include genetic, RNA splicing, DNA methylation, histone H3 modification, microRNA expression and reverse-phase protein array data for 1,072 cell lines from individuals of various lineages and ethnicities. Integration of these data with functional characterizations such as drug-sensitivity, short hairpin RNA knockdown and CRISPR-Cas9 knockout data reveals potential targets for cancer drugs and associated biomarkers. Together, this dataset and an accompanying public data portal provide a resource for the acceleration of cancer research using model cancer cell lines.

引用

页码：503 / +

页数：25

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