Total synthesis of (-)-callystatin A

被引：61
|
作者：
Langille, NF
Panek, JS
机构：
[1] Boston Univ, Dept Chem, Boston, MA 02215 USA
[2] Boston Univ, Ctr Chem Methodol & Library Dev, Metcalf Ctr Sci & Engn, Boston, MA 02215 USA
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 18期
关键词：
D O I：
10.1021/ol048664r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convergent enantioselective synthesis of the natural product (-)-callystatin A (1) is described. Key features of the synthesis include a lipase-mediated kinetic resolution to install the C5 lactone stereochemistry, a hydrozirconation-based approach to the C8-C9 trisubstituted (Z)-olefin, and a stereoselective cross-coupling of a vinyl dibromide to install the C14-C15 trisubstituted (E)-olefin.
引用
收藏
页码：3203 / 3206
页数：4
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