Exosomal noncoding RNAs in prostate cancer

被引：29

作者：

Movahedpour, Ahmad ^{[1
]}

Khatami, Seyyed Hossein ^{[2
]}

Karami, Neda ^{[3
]}

Vakili, Omid ^{[4
]}

Naeli, Parisa ^{[5
]}

Jamali, Zeinab ^{[6
]}

Shabaninejad, Zahra ^{[7
]}

Tazik, Khalil ^{[8
]}

Behrouj, Hamid ^{[1
]}

Ghasemi, Hassan ^{[9
]}

机构：

[1] Behbahan Fac Med Sci, Behbahan, Iran

[2] Shahid Beheshti Univ Med Sci, Sch Med, Dept Clin Biochem, Tehran, Iran

[3] Shiraz Univ Med Sci, Epilepsy Res Ctr, Shiraz, Iran

[4] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran

[5] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland

[6] Univ Tehran Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[7] Tarbiat Modares Univ, Fac Biol Sci, Dept Nanobiotechnol, Tehran, Iran

[8] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Gen Courses, Ahvaz, Iran

[9] Abadan Univ Med Sci, Abadan, Iran

来源：

CLINICA CHIMICA ACTA | 2022年 / 537卷

关键词：

Prostate cancer; Exosome; NcRNA; Biomarker; Diagnosis; EXTRACELLULAR VESICLES; BIOMARKERS; DIAGNOSIS; IDENTIFICATION; POLYMORPHISMS; SAMPLE; MIRNAS; RISK;

D O I：

10.1016/j.cca.2022.10.018

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Prostate cancer (PCa) is the second most common cancer and the fifth leading cause of mortality among men. The recurrent reports of false-positive results of common PCa biomarkers have led to the introduction of some promising biomarkers for PCa, such as exosomal non-coding RNAs (ncRNAs). Exosomes contain various components, such as several ncRNAs (miRNAs and lncRNAs), which are important in the initiation and progression of PCa. These ncRNAs also reflect the state of the origin cell. In this article, we reviewed research on the importance and roles of ncRNAs in PCa, focusing on exosomal ncRNAs. We highlighted plasma exosomal miRNAs (8 miRNAs), urine exosomal miRNAs (19miRNAs), serum miRNAs (2 miRNAs), and five miRNAs in semen used for PCa diagnosis. Also, four exosomal lncRNAs in plasma and urine can be used as biomarkers for PCa diagnosis.

引用

页码：127 / 132

页数：6

共 62 条

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