In situ formation of a heterobimetallic chiral [(salen)TiIV]/[(salen)VV] catalyst for the asymmetric addition of TMSCN to benzaldehyde

被引：49

作者：

Belokon, YN

North, M

Maleev, VI

Voskoboev, NV

Moskalenko, MA

Peregudov, AS

Dmitriev, AV

Ikonnikov, NS

Kagan, HB

机构：

[1] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia

[2] Univ Paris 11, Lab Synth Asymetr, UMR 8075, Inst Chim Mol & Mat Orsay, F-91405 Orsay, France

[3] Kings Coll London, Dept Chem, London WC2R 2LS, England

[4] Russian Acad Sci, Higher Chem Coll, Moscow 125047, Russia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 31期

关键词：

asymmetric catalysis; cooperative effects; heterobimetallic complexes; titanium; vanadium;

D O I：

10.1002/anie.200454031

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mixed complex which results from two salen-derived VV and TiIV complexes (1 and 2), catalyzes the trimethylsilylcyanation of aldehydes. The reaction kinetics are largely determined by the titanium-derived portion, whereas the configuration of the mandelonitrile trimethylsilyl ether products is determined by the slower vanadium part of the catalyst. salen = N, N′-bis (salicylaldehydo) ethyl-enediamine.

引用

页码：4085 / 4089

页数：5

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