Toll like receptor 4: Link to the anti-inflammatory effects of exercise?

被引：96

作者：

Flynn, Michael G.

McFarlin, Brian K.

机构：

[1] Purdue Univ, Dept Hlth & Kinesiol, Wastl Human Performance Lab, W Lafayette, IN 47907 USA

[2] Univ Houston, Dept Hlth & Human Performance, Houston, TX USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2006年 / 34卷 / 04期

关键词：

inflammation; toll-like receptor 4; anti-inflammatory; lipopolysaccharide; physical activity;

D O I：

10.1249/01.jes.0000240027.22749.14

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Evidence is emerging that exercise training has anti-inflammatory effects. Our early finding that blood cultures from trained subject had a reduced responsiveness to lipopolysaccharide led to a series of studies in which we measured toll-like receptor 4-the primary signaling receptor for lipopolysaccharide. The toll-like receptor 4 expression was consistently lower in physically active subjects compared with inactive subjects and reduced after training in previously inactive subjects.

引用

收藏

页码：176 / 181

页数：6

相关论文

共 17 条

[1] Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses [J].

Beg, AA .

TRENDS IN IMMUNOLOGY, 2002, 23 (11) :509-512

[2] Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects [J].

Bruun, JM ;

Helge, JW ;

Richelsen, B ;

Stallknecht, B .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2006, 290 (05) :E961-E967

[3] Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction [J].

Chow, JC ;

Young, DW ;

Golenbock, DT ;

Christ, WJ ;

Gusovsky, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :10689-10692

[4] Toll-like receptor 4 and CD14 mRNA expression are lower in resistive exercise-trained elderly women [J].

Flynn, MG ;

McFarlin, BK ;

Phillips, MD ;

Stewart, LK ;

Timmerman, KL .

JOURNAL OF APPLIED PHYSIOLOGY, 2003, 95 (05) :1833-1842

[5] Exercise training in chronic heart failure:: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle [J].

Gielen, S ;

Adams, V ;

Linke, A ;

Erbs, S ;

Möbius-Winkler, S ;

Schubert, A ;

Schuler, G ;

Hambrecht, R .

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, 2005, 12 (04) :393-400

[6] Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans [J].

Greiwe, JS ;

Cheng, B ;

Rubin, DC ;

Yarasheski, KE ;

Semenkovich, CF .

FASEB JOURNAL, 2001, 15 (02) :475-482

[7] Inhibition of toll-like receptor and cytokine signaling -: A unifying theme in ischemic tolerance [J].

Karikó, K ;

Weissman, D ;

Welsh, FA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2004, 24 (11) :1288-1304

[8] Host tissue damage signal ATP promotes non-directional migration and negatively regulates Toll-like receptor signaling in human monocytes [J].

Kaufmann, A ;

Musset, B ;

Limberg, SH ;

Renigunta, V ;

Sus, R ;

Dalpke, AH ;

Heeg, KM ;

Robaye, B ;

Hanley, PJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (37) :32459-32467

[9] HSP60 induces self-tolerance to repeated HSP60 stimulation and cross-tolerance to other pro-inflammatory stimuli [J].

Kilmartin, B ;

Reen, DJ .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (07) :2041-2051

[10] Modulatory effects of sCD14 and LBP on LPS-host cell interactions [J].

Kitchens, RL ;

Thompson, PA .

JOURNAL OF ENDOTOXIN RESEARCH, 2005, 11 (04) :225-229