SUBLETHAL EFFECTS OF SUBACUTE EXPOSURE TO RDX (1,3,5-TRINITRO-1,3,5-TRIAZINE) IN THE NORTHERN BOBWHITE (COLINUS VIRGINIANUS)

被引：16

作者：

Quinn, Michael J., Jr. ^{[1
]}

Bazar, Matthew A. ^{[1
]}

McFarland, Craig A. ^{[1
]}

Perkins, Edward J. ^{[2
]}

Gust, Kurt A. ^{[2
]}

Johnson, Mark S. ^{[1
]}

机构：

[1] USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, Aberdeen Proving Ground, MD 21010 USA

[2] USA, Ctr Res Dev & Engn, Environm Lab, Vicksburg, MS 39180 USA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2009年 / 28卷 / 06期

关键词：

RDX (1,3,5-trinitro-1,3,5-triazine); Northern bobwhite; Birds; Explosive; TOXICITY;

D O I：

10.1897/08-418.1

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Northern bobwhite (Colinus virginianus) were orally exposed via gavage to 0, 0.5, 3, 8, 12, or 17 mg/kg of RDX (1,3,5-trinitro-1,3,5-triazine) in corn oil daily for 14 d to evaluate sublethal effects of this explosive in birds. Mortality occurred at a rates of 100, 67, and 25% for the 17, 12, and 8 mg/kg/d dose groups, respectively. Death was preceded by clonic and tonic convulsions and weight loss caused by gastrointestinal effects. Increases in serum globulin and total leukocytes were observed in the two highest-dose groups. Degeneration of testicular and splenic tissue also was observed. The no-observed-adverse-effects and lowest-observed-adverse-effects levels were determined as 3.0 and 8.0 mg/kg/d, respectively.

引用

页码：1266 / 1270

页数：5

共 9 条

[1]

[Anonymous], TOX PROF RDX

[2]

*ENV ENG, 1980, ADB0533626

[3] Dietary oral exposure to 1,3,5-trinitro-1,3,5-triazine in the northern bobwhite (Colinus virginianus) [J].

Gogal, RM ;

Johnson, MS ;

Larsen, CT ;

Prater, MR ;

Duncan, RB ;

Ward, DL ;

Lee, RB ;

Salice, CJ ;

Jortner, B ;

Holladay, SD .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2003, 22 (02) :381-387

[4] Subacute toxicity of oral 2,6-dinitrotoluene and 1,3,5-trinitro-1,3,5-triazine (RDX) exposure to the northern bobwhite (Colinus virginianus) [J].

Johnson, Mark S. ;

Quinn, Michael J. ;

Bazar, Matthew A. ;

Gust, Kurt A. ;

Escalon, B. Lynn ;

Perkins, Edward J. .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2007, 26 (07) :1481-1487

[5] Effects of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in zebrafish:: General and reproductive toxicity [J].

Mukhi, Sandeep ;

Patino, Reynaldo .

CHEMOSPHERE, 2008, 72 (05) :726-732

[6]

Spanggord R.J., 1980, Environmental fate studies on certain munitions wastewater constituents

[7]

final report, phase I -Literature review

[8]

Talmage Sylvia S., 1999, Reviews of Environmental Contamination and Toxicology, V161, P1

[9]

*US ARM CTR HLTH P, 2009, WILDL TOX ASS HLTH E

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