Uremic Toxins and Clinical Outcomes: The Impact of Kidney Transplantation

被引：34

作者：

Liabeuf, Sophie ^{[1
,2
,3
]}

Cheddani, Lynda ^{[4
,5
,6
]}

Massy, Ziad A. ^{[4
,5
,6
]}

机构：

[1] Amiens Univ, Div Clin Pharmacol, Med Ctr, F-80054 Amiens, France

[2] Amiens Univ, Dept Clin Res, Med Ctr, F-80054 Amiens, France

[3] Jules Verne Univ Picardie, EA 7517, Lab MP3CV, CURS, F-80054 Amiens, France

[4] Ambroise Pare Univ, Med Ctr, AP HP, Div Nephrol, F-92100 Paris, France

[5] Paris Saclay Univ, CESP Ctr Rech Epidemiol & Sante Populat, INSERM, U1018,Team 5, F-94800 Villejuif, France

[6] Paris Ouest Versailles St Quentin En Yvelines Uni, F-94800 Villejuif, France

来源：

TOXINS | 2018年 / 10卷 / 06期

关键词：

uremic toxins; chronic kidney disease; renal transplantation; outcomes; GROWTH-FACTOR; 23; LEFT-VENTRICULAR HYPERTROPHY; TRIMETHYLAMINE-N-OXIDE; GLOMERULAR-FILTRATION-RATE; STAGE RENAL-DISEASE; ALL-CAUSE MORTALITY; PULSE-WAVE VELOCITY; P-CRESYL SULFATE; SERUM PHOSPHATE; VASCULAR CALCIFICATION;

D O I：

10.3390/toxins10060229

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Non-transplanted and transplanted patients with chronic kidney disease (CKD) differ in terms of mortality and the risk of clinical events. This difference is probably due to the difference of both traditional and non-traditional risk factors. Uremic retention solutes may constitute important non-traditional risk factors in this population. In the present review, we selected a set of uremic toxins that have been associated with harmful effects, and are an appealing target for adjuvant therapy in CKD. For each toxin reviewed here, relevant studies were selected and the relationship with hard clinical outcomes of uremic toxins were compared between non-transplanted CKD patients and transplanted patients taking into account the level of glomerular filtration rate in these two situations.

引用

页数：18

共 129 条

[1] Left ventricular hypertrophy: Is hyperphosphatemia among dialysis patients a risk factor? [J].

Achinger, Steven G. ;

Ayus, Juan Carlos .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 :S255-S261

[2] Association of Serum Phosphate with Vascular and Valvular Calcification in Moderate CKD [J].

Adeney, Kathryn L. ;

Siscovick, David S. ;

Ix, Joachim H. ;

Seliger, Stephen L. ;

Shlipak, Michael G. ;

Jenny, Nancy S. ;

Kestenbaum, Bryan R. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (02) :381-387

[3] Fibroblast Growth Factor-23 Levels Are Associated With Uric Acid But Not Carotid Intima Media Thickness in Renal Transplant Recipients [J].

Asicioglu, E. ;

Kahveci, A. ;

Arikan, H. ;

Koc, M. ;

Tuglular, S. ;

Ozener, C. .

TRANSPLANTATION PROCEEDINGS, 2014, 46 (01) :180-183

[4] Effects of short daily versus conventional hemodialysis on left ventricular hypertrophy and inflammatory markers:: A prospective, controlled study [J].

Ayus, JC ;

Mizani, MR ;

Achinger, SG ;

Thadhani, R ;

Go, AS ;

Lee, SK .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (09) :2778-2788

[5] The Influence of Glomerular Filtration Rate and Age on Fibroblast Growth Factor 23 Serum Levels in Pediatric Chronic Kidney Disease [J].

Bacchetta, Justine ;

Dubourg, Laurence ;

Harambat, Jerome ;

Ranchin, Bruno ;

Abou-Jaoude, Pauline ;

Arnaud, Simone ;

Carlier, Marie-Christine ;

Richard, Michel ;

Cochat, Pierre .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (04) :1741-1748

[6] Phosphate and FGF-23 homeostasis after kidney transplantation [J].

Baia, Leandro C. ;

Heilberg, Ita Pfeferman ;

Navis, Gerjan ;

de Borst, Martin H. .

NATURE REVIEWS NEPHROLOGY, 2015, 11 (11) :656-666

[7] Fibroblast Growth Factor 23 and Cardiovascular Mortality after Kidney Transplantation [J].

Baia, Leandro C. ;

Humalda, Jelmer K. ;

Vervloet, Marc G. ;

Navis, Gerjan ;

Bakker, Stephan J. L. ;

de Borst, Martin H. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 8 (11) :1968-1978

[8] Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis [J].

Bain, MA ;

Faull, R ;

Fornasini, G ;

Milne, RW ;

Evans, AM .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (05) :1300-1304

[9] Absolute Rates of Heart Failure, Coronary Heart Disease, and Stroke in Chronic Kidney Disease An Analysis of 3 Community-Based Cohort Studies [J].

Bansal, Nisha ;

Katz, Ronit ;

Robinson-Cohen, Cassianne ;

Odden, Michelle C. ;

Dalrymple, Lorien ;

Shlipak, Michael G. ;

Sarnak, Mark J. ;

Siscovick, David S. ;

Zelnick, Leila ;

Psaty, Bruce M. ;

Kestenbaum, Bryan ;

Correa, Adolfo ;

Afkarian, Maryam ;

Young, Bessie ;

de Boer, Ian H. .

JAMA CARDIOLOGY, 2017, 2 (03) :314-318

[10] Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients [J].

Barreto, Fellype C. ;

Barreto, Daniela V. ;

Liabeuf, Sophie ;

Meert, Natalie ;

Glorieux, Griet ;

Temmar, Mohammed ;

Choukroun, Gabriel ;

Vanholder, Raymond ;

Massy, Ziad A. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 4 (10) :1551-1558

← 1 2 3 4 5 6 7 8 9 10 →