First Synthesis of Thiophene Thioglycosides

被引:25
作者
Elgemeie, Galal H. [1 ]
Zaghary, Wafaa A. [2 ]
Amin, Kamelia M. [3 ]
Nasr, Tamer M. [2 ]
机构
[1] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt
[2] Helwan Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, Egypt
[3] Cairo Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, Egypt
关键词
Thiophene thioglycosides; Sodium thiophenethiolate; Galacto-pyranosyl bromides; NUCLEOSIDES;
D O I
10.1080/07328300902789209
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new method for the preparation of a new class of thiophene thioglycosides via one-pot reaction of the sodium thiophenethiolate salts with 2,3,4,6-tetra-O-acetyl--D-gluco- and galacto-pyranosyl bromides has been studied. The sodium thiophenethiolate salts are prepared using cyano-di-thioic analogs and their corresponding mono- and dithiolate salts.
引用
收藏
页码:161 / 178
页数:18
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