Chrotacumines G-J, chromone alkaloids from Dysoxylum acutangulum with osteoclast differentiation inhibitory activity

被引：16
|
作者：
Morita, Hiroshi [1 ]
Nugroho, Alfarius Eko [1 ]
Nagakura, Yuta [1 ]
Hirasawa, Yusuke [1 ]
Yoshida, Haruka [1 ]
Kaneda, Toshio [1 ]
Shirota, Osamu [2 ]
Ismail, Intan Safinar [3 ]
机构：
[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan
[2] Tokushima Bunri Univ, Fac Pharmaceut Sci, Sanuki City, Kagawa 7692193, Japan
[3] Univ Putra Malaysia, Lab Nat Prod, Inst Biosci, Serdang 43400, Malaysia
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 11期
基金：
日本学术振兴会;
关键词：
Chrotacumines; Meliaceae; Dysoxylum; Activity; Alkaloids; ACID-PHOSPHATASE; 5B; MARKER;
D O I：
10.1016/j.bmcl.2014.04.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new chromone alkaloids, chrotacumines G-J (1-4), have been isolated from the barks of Dysoxylum acutangulum. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Chrotacumines G and J (1 and 4) showed osteoclast differentiation inhibitory activity in a dose dependent manner. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2437 / 2439
页数：3
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