Effects of acidosis and Fe (II) on lipid peroxidation in phospholipid extract: Comparative effect of diphenyl diselenide and ebselen

The influence of acidosis on lipid peroxidation in phospholipids extract from egg yolk was studied. In addition, we have also tested the effect of pH on the anti-oxidant properties of diphenyl diselenide and ebselen. Acidosis increased rate of lipid peroxidation both in the absence and presence of Fe (II). Diphenyl diselenide significantly protected TBARS production at all studied pH values while ebselen offered only a small statistically non-significant protection. However, changing the pH of the reaction medium did not alter the anti-oxidant activity of the tested compounds. This study provides in vitro evidence for acidosis-induced oxidative stress in phospholipids extract and anti-oxidant action of Biphenyl diselenide. (C) 2009 Elsevier B.V. All rights reserved.