Synthetic yeast brews neuroactive compounds

被引：6

作者：

Gu, Yang ^{[1
,2
]}

Xu, Peng ^{[1
]}

机构：

[1] Univ Maryland Baltimore Cty, Dept Chem Biochem & Environm Engn, Baltimore, MD 21228 USA

[2] Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing, Peoples R China

来源：

NATURE CHEMICAL BIOLOGY | 2021年 / 17卷 / 01期

关键词：

D O I：

10.1038/s41589-020-00691-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.

引用

页码：8 / 9

页数：2

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