Cannabinoids in the Treatment of Back Pain

被引：13

作者：

Kim, Teddy E. ^{[1
]}

Townsend, Robert K. ^{[1
]}

Branch, Charles L. ^{[1
]}

Romero-Sandoval, Edgar A. ^{[2
]}

Hsu, Wesley ^{[1
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Neurosurg, 1 Med Ctr Blvd, Winston Salem, NC 27157 USA

[2] Wake Forest Univ, Bowman Gray Sch Med, Dept Anesthesiol, Winston Salem, NC 27157 USA

来源：

NEUROSURGERY | 2020年 / 87卷 / 02期

关键词：

Cannabinoid; Cannabidiol; Marijuana; THC; Back pain; Inflammation; Neuropathy; Postoperative pain; CBD; Delta(9)-Tetrahydrocannabinol; Opioid epidemic; OPIOID RECEPTOR AGONISTS; DRUG-RESISTANT SEIZURES; ACID AMIDE HYDROLASE; NEUROPATHIC PAIN; ENDOCANNABINOID SYSTEM; CB2; RECEPTORS; MEDICAL MARIJUANA; MOLECULAR CHARACTERIZATION; RESPIRATORY DEPRESSION; POSTOPERATIVE PAIN;

D O I：

10.1093/neuros/nyz573

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Marijuana is increasingly utilized for the treatment of multiple medical problems, including back pain, in the United States. Although there is strong preclinical evidence supporting the promise of cannabinoids in the treatment of back pain, there is a paucity of clinical data supporting their use in clinical practice. Opioids are an important medication for the treatment of acute and chronic back pain, but utilization of opioid-based regimens have likely contributed to the growing opioid epidemic. The significant risk of morbidity, mortality, and dependence secondary to opioid medications have increased the interest in nonopioid medications, including cannabinoid-based pain regimens, in treating back pain. This review will provide an overview on the pharmacology, drug delivery methods, clinical evidence, and safety considerations critical to understanding the potential role of cannabinoids in the treatment of back pain.

引用

页码：166 / 175

页数：10

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