Radionuclide Therapy for Neuroendocrine Tumors

被引：110
作者：
Cives, Mauro [1 ]
Strosberg, Jonathan [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Gastrointestinal Oncol, 12902 Magnolia Dr, Tampa, FL 33612 USA
来源：
CURRENT ONCOLOGY REPORTS | 2017年 / 19卷 / 02期
关键词：
Carcinoid tumors; PRRT; Radiolabeled somatostatin analogs; Lutetium; NETTER-1; RADIOLABELED SOMATOSTATIN ANALOG; RECEPTOR CHEMORADIONUCLIDE THERAPY; PHASE I-II; RADIOPEPTIDE LU-177-OCTREOTATE; LU-177-DOTATATE; Y-90-DOTATOC; SURVIVAL; COMBINATION; CAPECITABINE; EXPERIENCE;
D O I：
10.1007/s11912-017-0567-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Peptide receptor radionuclide therapy (PRRT) is a form of systemic radiotherapy that allows targeted delivery of radionuclides to tumor cells expressing high levels of somatostatin receptors. The two radiopeptides most commonly used for PRRT, Y-90-DOTATOC and Lu-177-DOTATATE, have been successfully employed for more than a decade for the treatment of advanced neuroendocrine tumors (NETs). Recently, the phase III, randomized NETTER-1 trial has compared Lu-177-DOTATATE versus high-dose octreotide LAR in patients with progressive, metastatic midgut NETs, demonstrating exceptional tolerability and efficacy. This review summarizes recent developments in the field of radionuclide therapy for gastroenteropancreatic and lung NETs and considers possible strategies to further enhance its clinical efficacy.
引用
收藏
页数：9
相关论文
共 71 条
[61]   Report on short-term side effects of treatments with 177Lu-octreotate in combination with capecitabine in seven patients with gastroenteropancreatic neuroendocrine tumours [J].
van Essen, Martijn ;
Krenning, Eric P. ;
Kam, Boen L. ;
de Herder, Wouter W. ;
van Aken, Maarten O. ;
Kwekkeboom, Dik J. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2008, 35 (04) :743-748
[62]   Peptide Receptor Radionuclide Therapy with radiolabelled somatostatin analogues in patients with somatostatin receptor positive tumours [J].
Van Essen, Martijn ;
Krenning, Eric P. ;
De Jong, Marion ;
Valkema, Roelf ;
Kwekkeboom, Dik J. .
ACTA ONCOLOGICA, 2007, 46 (06) :723-734
[63]   Salvage Therapy with 177Lu-Octreotate in Patients with Bronchial and Gastroenteropancreatic Neuroendocrine Tumors [J].
van Essen, Martijn ;
Krenning, Eric P. ;
Kam, Boen L. R. ;
de Herder, Wouter W. ;
Feelders, Richard A. ;
Kwekkeboom, Dik J. .
JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (03) :383-390
[64]   Neoadjuvant Treatment of Nonfunctioning Pancreatic Neuroendocrine Tumors with [177Lu-DOTA0,Tyr3]Octreotate [J].
van Vliet, Esther I. ;
van Eijck, Casper H. ;
de Krijger, Ronald R. ;
van Dijkum, Elisabeth J. Nieveen ;
Teunissen, Jaap J. ;
Kam, Boen L. ;
de Herder, Wouter W. ;
Feelders, Richard A. ;
Bonsing, Bert A. ;
Brabander, Tessa ;
Krenning, Eric P. ;
Kwekkeboom, Dik J. .
JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (11) :1647-1653
[65]   Cohort Study of Somatostatin-Based Radiopeptide Therapy With [90Y-DOTA]-TOC Versus [90Y-DOTA]-TOC Plus [177Lu-DOTA]-TOC in Neuroendocrine Cancers [J].
Villard, Linda ;
Romer, Anna ;
Marincek, Nicolas ;
Brunner, Philippe ;
Koller, Michael T. ;
Schindler, Christian ;
Ng, Quinn K. T. ;
Maecke, Helmut R. ;
Mueller-Brand, Jan ;
Rochlitz, Christoph ;
Briel, Matthias ;
Walter, Martin A. .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (10) :1100-1106
[66]  
Waldherr C, 2002, J NUCL MED, V43, P610
[67]   Comparison of Somatostatin Receptor Agonist and Antagonist for Peptide Receptor Radionuclide Therapy: A Pilot Study [J].
Wild, Damian ;
Fani, Melpomeni ;
Fischer, Richard ;
Del Pozzo, Luigi ;
Kaul, Felix ;
Krebs, Simone ;
Fischer, Richard ;
Rivier, Jean E. F. ;
Reubi, Jean Claude ;
Maecke, Helmut R. ;
Weber, Wolfgang A. .
JOURNAL OF NUCLEAR MEDICINE, 2014, 55 (08) :1248-1252
[68]   Induction of Anti-Tumor Immune Responses by Peptide Receptor Radionuclide Therapy with Lu-177-DOTATATE in a Murine Model of a Human Neuroendocrine Tumor [J].
Wu, Yin ;
Pfeifer, Andreas Klaus ;
Myschetzky, Rebecca ;
Garbyal, Rajendra Singh ;
Rasmussen, Palle ;
Knigge, Ulrich ;
Bzorek, Michael ;
Kristensen, Michael Holmsgaard ;
Kjaer, Andreas .
DIAGNOSTICS, 2013, 3 (04) :344-355
[69]  
Yang F, 2014, NEW ENGL J MED, V371, P1556, DOI [10.1056/NEJMoa1316158, 10.1056/NEJMc1409757]
[70]   One hundred years after "Carcinoid": Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States [J].
Yao, James C. ;
Hassan, Manal ;
Phan, Alexandria ;
Dagohoy, Cecile ;
Leary, Colleen ;
Mares, Jeannette E. ;
Abdalla, Eddie K. ;
Fleming, Jason B. ;
Vauthey, Jean-Nicolas ;
Rashid, Asif ;
Evans, Douglas B. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (18) :3063-3072
12345678