Radionuclide Therapy for Neuroendocrine Tumors

被引：106
作者：
Cives, Mauro [1 ]
Strosberg, Jonathan [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Gastrointestinal Oncol, 12902 Magnolia Dr, Tampa, FL 33612 USA
来源：
CURRENT ONCOLOGY REPORTS | 2017年 / 19卷 / 02期
关键词：
Carcinoid tumors; PRRT; Radiolabeled somatostatin analogs; Lutetium; NETTER-1; RADIOLABELED SOMATOSTATIN ANALOG; RECEPTOR CHEMORADIONUCLIDE THERAPY; PHASE I-II; RADIOPEPTIDE LU-177-OCTREOTATE; LU-177-DOTATATE; Y-90-DOTATOC; SURVIVAL; COMBINATION; CAPECITABINE; EXPERIENCE;
D O I：
10.1007/s11912-017-0567-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Peptide receptor radionuclide therapy (PRRT) is a form of systemic radiotherapy that allows targeted delivery of radionuclides to tumor cells expressing high levels of somatostatin receptors. The two radiopeptides most commonly used for PRRT, Y-90-DOTATOC and Lu-177-DOTATATE, have been successfully employed for more than a decade for the treatment of advanced neuroendocrine tumors (NETs). Recently, the phase III, randomized NETTER-1 trial has compared Lu-177-DOTATATE versus high-dose octreotide LAR in patients with progressive, metastatic midgut NETs, demonstrating exceptional tolerability and efficacy. This review summarizes recent developments in the field of radionuclide therapy for gastroenteropancreatic and lung NETs and considers possible strategies to further enhance its clinical efficacy.
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页数：9
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