Critical illness polyneuropathy- and myopathy: a systematic reviewu

被引:105
作者
Zhou, Chunkui [1 ]
Wu, Limin [1 ,2 ]
Ni, Fengming [3 ]
Ji, Wei [4 ]
Wu, Jiang [1 ]
Zhang, Hongliang [1 ]
机构
[1] Jilin Univ, Bethune Hosp 1, Dept Neurol, Changchun 130021, Jilin Province, Peoples R China
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Neuroprotect Res Lab, Charlestown, MA 02129 USA
[3] Jilin Univ, Bethune Hosp 1, Ctr Oncol, Dept Radiotherapy, Changchun 130021, Jilin Province, Peoples R China
[4] Peoples Hosp Jilin Prov, Dept Vasc Surg, Changchun 130000, Jilin Province, Peoples R China
基金
中国国家自然科学基金;
关键词
nerve regeneration; neurodegenerative diseases; critical illness polyneuropathy; critical illness myopathy; intensive care unit; sepsis; multiple organ failure; Guillain-Barre syndrome; NSFC grant; neural regeneration; INTENSIVE INSULIN THERAPY; NEUROMUSCULAR ELECTRICAL-STIMULATION; GUILLAIN-BARRE-SYNDROME; CARE-UNIT; SKELETAL-MUSCLE; RISK-FACTORS; NEUROLOGICAL COMPLICATIONS; FAST INACTIVATION; PERIPHERAL-NERVE; SODIUM-CHANNEL;
D O I
10.4103/1673-5374.125337
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles, respectively. Clinically, they manifest as limb and respiratory muscle weakness. Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation. Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event. Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy. Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population. The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical, diagnostic, differentiating, and treatment information for this debilitating neurological disease.
引用
收藏
页码:101 / 110
页数:10
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