microRNA-mediated regulation of the tumor microenvironment

被引:139
作者
Chou, Jonathan [1 ,2 ]
Shahi, Payam [1 ]
Werb, Zena [1 ,2 ]
机构
[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Program Biomed Sci, San Francisco, CA 94143 USA
基金
美国国家卫生研究院;
关键词
COLONY-STIMULATING FACTOR; BREAST-CANCER CELLS; CARCINOMA IN-SITU; DOWN-REGULATION; MAMMARY-GLAND; LYSYL OXIDASE; MESSENGER-RNAS; LUNG-CANCER; METASTASIS; EXPRESSION;
D O I
10.4161/cc.26087
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The tumor microenvironment includes cells such as fibroblasts, immune cells, endothelial cells, as well as extracellular matrix (ECM), proteases, and cytokines. Together, these components participate in a complex crosstalk with neoplastic tumor cells that affects growth, angiogenesis, and metastasis. MicroRNAs (miRNAs) are small, non-coding RNAs involved in post-transcriptional regulation of gene expression and have recently emerged as important players involved in regulating multiple aspects of cancer biology and the tumor microenvironment. Differential miRNA expression in both the epithelial and stromal compartments of tumors compared with normal tissue suggests that miRNAs are important drivers of tumorigenesis and metastasis. This review article summarizes our current understanding of the diverse roles of miRNAs involved in tumor microenvironment regulation and underscores the importance of miRNAs within multiple cell types that contribute to the hallmarks of cancer.
引用
收藏
页码:3262 / 3271
页数:10
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