Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection

被引：145

作者：

Korupalli, Chiranjeevi ^{[1
,2
]}

Huang, Chieh-Cheng ^{[1
,2
]}

Lin, Wei-Chih ^{[1
,2
]}

Pan, Wen-Yu ^{[1
,2
]}

Lin, Po-Yen ^{[1
,2
]}

Wan, Wei-Lin ^{[1
,2
]}

Li, Meng-Ju ^{[3
]}

Chang, Yen ^{[4
,5
]}

Sung, Hsing-Wen ^{[1
,2
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan

[2] Natl Tsing Hua Univ, Inst Biomed Engn, Hsinchu, Taiwan

[3] Natl Taiwan Univ Hosp, Hsinchu Branch, Dept Pediat, Hsinchu, Taiwan

[4] Natl Yang Ming Univ, Cheng Hsin Gen Hosp, Ctr Heart, Dept Cardiovasc Surg, Taipei, Taiwan

[5] Natl Yang Ming Univ, Coll Med, Taipei, Taiwan

来源：

BIOMATERIALS | 2017年 / 116卷

关键词：

Subcutaneous abscesses; Photothermal therapy; pH-responsive nanoparticles; Charge conversion; Imaging guiding; POLYANILINE NANOPARTICLES; RESISTANT BACTERIA; HYDROGELS; THERAPY; AUREUS; HYPERTHERMIA; ABSCESSES; SYSTEM; CELLS; LIGHT;

D O I：

10.1016/j.biomaterials.2016.11.045

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that Is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood. The local temperature of the NIR-irradiated PANI-GCS NPs is estimated to be approximately 5 degrees C higher than their ambient tissue temperature, ensuring specific and direct heating of their aggregated bacteria; hence, damage to tissue is reduced and wound healing is accelerated. The above results demonstrate that PANI-GCS NPs are practical for use in the photothermal ablation of focal infections. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1 / 9

页数：9

共 27 条

[1] A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses [J].