Lavender and dodder combined herbal syrup versus citalopram in major depressive disorder with anxious distress: A double-blind randomized trial

被引:6
作者
Firoozeei, Toktam Sadat [1 ]
Barekatain, Majid [2 ]
Karimi, Mehrdad [1 ]
Zargaran, Arman [3 ]
Akhondzadeh, Shahin [4 ]
Rezaeizadeh, Hossein [1 ]
机构
[1] Univ Tehran Med Sci, Sch Persian Med, Dept Persian Med, Tehran 1668753961, Iran
[2] Isfahan Univ Med Sci, Sch Med, Dept Psychiat, Esfahan 8145831451, Iran
[3] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, Tehran 1668753961, Iran
[4] Univ Tehran Med Sci, Roozbeh Hosp, Psychiat Res Ctr, Tehran 1449614353, Iran
来源
JOURNAL OF INTEGRATIVE MEDICINE-JIM | 2020年 / 18卷 / 05期
关键词
Persian medicine; Traditional medicine; Anxiety; Depression; Phytotherapy; Lavender; Dodder; Citalopram; LAVANDULA-ANGUSTIFOLIA MILL; NEPETA-MENTHOIDES BOISS; CUSCUTA-CHINENSIS LAM; ROSMARINIC ACID; ANXIETY DISORDER; OXIDATIVE STRESS; AQUEOUS EXTRACT; OIL PREPARATION; CAFFEIC ACID; PLACEBO;
D O I
10.1016/j.joim.2020.06.002
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Background: Major depressive disorder (MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Persian medicine, lavender-dodder syrup is one formula often recommended for such disorders. Objective: This study compares the effects of lavender-dodder syrup to the standard drug, citalopram, for treating MDD with anxious distress. Design, setting, participants and intervention: This six-week, double-blind, randomized, clinical trial was carried out in a psychiatric outpatient clinic. During the six-week intervention period, patients in citalopram group received citalopram tablets 20 mg/d plus 5 mL placebo syrup every 12 h; patients in group B received placebo tablets once daily plus 5 mL of lavender-dodder herbal syrup every 12 h. Main outcome measures: Primary outcome measures, depression and anxiety, were evaluated using the Hamilton Depression/Anxiety Rating Scales, and were scored at the beginning of the study and at weeks three and six. Secondary outcome measures including response to treatment and remission rates were also compared between the two groups. Results: Fifty-six participants with MDD and anxious distress were randomly assigned to two groups. Mean depression scores significantly decreased in citalopram and herbal groups at weeks three and six (time effect: P < 0.001), although the observed changes were not significantly different between the groups (intervention effect: P = 0.61). Mean anxiety scores were not significantly different between the two groups at week three (P = 0.75). However, at the end of week six, the observed decrease was significantly higher in the herbal syrup group than the citalopram group (intervention effect: P = 0.007). Conclusion: The herbal syrup is an effective and tolerable supplement for treating MDD with anxious distress. (C) 2020 Shanghai Changhai Hospital. Published by ELSEVIER B.V. All rights reserved.
引用
收藏
页码:409 / 415
页数:7
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