Molecularly imprinted polymer-based, solid-phase extraction followed by liquid chromatographic determination of lacosamide in rat plasma

被引：3
作者：
Rao, R. Nageswara [1 ]
Sravan, B. [1 ]
Reddy, Ch. Krishna [2 ]
Meena, S. [3 ]
Prashamsa, J. [4 ]
Spoorthy, P. [5 ]
机构：
[1] Indian Inst Chem Technol, Div Analyt Chem, Hyderabad, Andhra Pradesh, India
[2] KM Coll Pharm, Madurai, Tamil Nadu, India
[3] Acharya & BM Reddy Coll Pharm, Bangalore, India
[4] Kakatiya Univ, Univ Coll Pharmaceut Sci, Warangal, Andhra Pradesh, India
[5] Gokaraju Rangaraju Coll Pharm, Hyderabad, Andhra Pradesh, India
来源：
ANALYTICAL METHODS | 2014年 / 6卷 / 09期
关键词：
PRECLINICAL PHARMACOKINETICS; ANTIEPILEPTIC DRUG; QUANTIFICATION;
D O I：
10.1039/c3ay42186d
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A novel sample clean-up technique, water-compatible, molecularly imprinted, solid-phase extraction (MISPE), combined with high-performance liquid chromatography (HPLC), was developed and validated for selective extraction and determination of lacosamide in rat plasma. The molecularly imprinted polymer (MIP) was synthesized using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, chloroform as a porogen, and lacosamide as a template. Its efficacy as a selective sorbent in solid-phase extraction of lacosamide and the effects of various porogenic solvents, pH, crosslinker, and amount of monomer were studied and optimized. The recovery was >98% with a detection limit of 0.03 mu g mL(-1) over a linear range of 0.1-100 mu g mL(-1).
引用
收藏
页码：3101 / 3107
页数：7
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