If and the biological pacemaker

被引：43
作者：
Robinson, Richard B.
Brink, Peter R.
Cohen, Ira S.
Rosen, Michael R.
机构：
[1] Columbia Univ, Dept Pharmacol, Ctr Mol Therapeut, New York, NY 10032 USA
[2] SUNY Stony Brook, Inst Mol Cardiol, Dept Physiol & Biophys, Stony Brook, NY 11794 USA
[3] Columbia Univ, Dept Pediat, New York, NY 10032 USA
来源：
PHARMACOLOGICAL RESEARCH | 2006年 / 53卷 / 05期
关键词：
biological pacemaker; HCN; automaticity; gene therapy; stem cells;
D O I：
10.1016/j.phrs.2006.03.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A biological pacemaker based on the HCN gene family, the molecular correlate of the native cardiac pacemaker current, holds promise of enhancing or supplanting current electronic pacemakers by providing autonomic responsiveness of cardiac rate. Gene-based and cell-based delivery of the HCN gene have been employed to produce biological pacemakers. This article reviews efforts to date to create gene- and cell-based biological pacemakers, using both the HCN gene family and other approaches, and discusses what is known about the autonomic responsiveness in each case. Possible future refinements to an HCN based biological pacemaker also are discussed. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：407 / 415
页数：9
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