One-Pot Multi-Component Synthesis and Solid State Structures of Functionally Rich Polyether Macrocycles

被引：22

作者：

Vishe, Mahesh ^{[1
]}

Hrdina, Radim ^{[1
]}

Guenee, Laure ^{[2
]}

Besnard, Celine ^{[2
]}

Lacour, Jerome ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, Crystallog Lab, CH-1211 Geneva, Switzerland

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 16期

基金：

瑞士国家科学基金会;

关键词：

catalysis; diazo carbonyl compounds; dirhodium complexes; macrocyclization; multi-component condensation reactions; C-H INSERTION; YLIDE FORMATION; INTRAMOLECULAR CYCLOPROPANATION; ENANTIOSELECTIVE SYNTHESIS; CARBENE INSERTION; DIRHODIUM(II); REARRANGEMENT; CATALYST; CYCLOADDITION; METHODOLOGY;

D O I：

10.1002/adsc.201300462

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Densely functionalized polyether macrocycles can be prepared in one pot in yields up to 60% by the rhodium(II)-catalyzed decomposition of methyl diazoacetoacetate in the presence of a variety of substituted or unsaturated 5- and 6-membered ring cyclic ethers. A comprehensive analysis of the solid state conformations of the macrocyclic geometries is detailed as well as novel mechanistic insights about the multi-component condensation reaction.

引用

页码：3161 / 3169

页数：9

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