Hydroxyapatite/poly-L-lactide acid screws have better biocompatibility and femoral burr hole closure than does poly-L-lactide acid alone

被引：13

作者：

Akagi, Hiroyuki ^{[1
]}

Iwata, Munetaka ^{[1
]}

Ichinohe, Tomu ^{[1
]}

Amimoto, Hirokazu ^{[1
]}

Hayashi, Yuuta ^{[1
]}

Kannno, Nobuo ^{[1
]}

Ochi, Hiroki ^{[2
]}

Fujita, Yukihiro ^{[3
]}

Harada, Yasuji ^{[1
]}

Tagawa, Masahiro ^{[1
]}

Hara, Yasushi ^{[1
]}

机构：

[1] Nippon Vet & Life Sci Univ, Fac Vet Med, Dept Vet Sci, Div Vet Surg, Tokyo 1808602, Japan

[2] Nippon Vet & Life Sci Univ, Fac Vet Med, Dept Vet Sci, Div Vet Microbiol, Tokyo 1808602, Japan

[3] Azabu Univ, Sch Vet Med, Lab Vet Surg, Chuou Ku, Sagamihara, Kanagawa, Japan

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2014年 / 28卷 / 06期

关键词：

Biomaterial; hydroxyapatite; poly-l-lactide; foreign body reaction; orthopedics; LONG-TERM; INTERNAL-FIXATION; COMPOSITE RODS; BONE-FRACTURES; PIN FIXATION; RABBITS; BEHAVIOR; SURGERY;

D O I：

10.1177/0885328213487754

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hydroxyapatite (HA)/poly-l-lactide(PLLA) composite biomaterials are available for orthopedic applications, but bioresorption and cell-mediated inflammation in bone cortex are unknown. We conducted an 84-month follow-up study with Beagle dogs that were subjected to implants with either PLLA (left femur) or HA/PLLA (right femur). Histological and radiographic analysis showed that HA/PLLA screws induced significant increases in HA content from 36 months onward and complete burr hole closure at 60 months, whereas PLLA screws did not. Moreover, PLLA screws induced more severe fibrous tissue and histiocyte infiltration. HA/PLLA screws promote earlier burr hole replacement and have superior biocompatibility compared to PLLA screws.

引用

页码：954 / 962

页数：9