CD8+ T-cells mediate immunopathology in tick-borne encephalitis

被引：108

作者：

Ruzek, Daniel ^{[1
,2
]}

Salat, Jiri ^{[1
,2
]}

Palus, Martin ^{[2
]}

Gritsun, Tamara S. ^{[3
]}

Gould, Ernest A. ^{[4
]}

Dykova, Iva ^{[1
]}

Skallova, Anna ^{[1
,2
]}

Jelinek, Jiri ^{[1
,2
]}

Kopecky, Jan ^{[1
,2
]}

Grubhoffer, Libor ^{[1
,2
]}

机构：

[1] Acad Sci Czech Republ, Inst Parasitol, Ctr Biol, CZ-37005 Ceske Budejovice, Czech Republic

[2] Univ S Bohemia, Fac Sci, CZ-37005 Ceske Budejovice, Czech Republic

[3] Univ Reading, Sch Biol Sci, Reading RG6 6AJ, Berks, England

[4] Ctr Ecol & Hydrol, Oxford OX2 8NN, England

来源：

VIROLOGY | 2009年 / 384卷 / 01期

关键词：

Tick-borne encephalitis virus; Immunopathology; CD8(+) T-cells; CD4(+) T-cells; SCID mice; WEST-NILE-VIRUS; UNTERSCHIEDLICH EMPFANGLICHEN WIRTEN; UND SUBKLINISCHEN FORMEN; ZECKENENCEPHALITIS; NEURONS; AFFEN;

D O I：

10.1016/j.virol.2008.11.023

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epidemics of tick-borne encephalitis involving thousands of humans occur annually in the forested regions of Europe and Asia. Despite the importance of this disease, the underlying basis for the development of encephalitis remains undefined. Here, we prove the key role of CD8(+) T-cells in the immunopathology of tick-borne encephalitis, as demonstrated by prolonged survival of SCID or CD8(-/-) mice, following infection, when compared with immunocompetent mice or mice with adoptively transferred CD8(+) T-cells. The results imply that tick-borne encephalitis is an immunopathological disease and that the inflammatory reaction significantly contributes to the fatal outcome of the infection. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1 / 6

页数：6

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