Antiproliferative potential of moluccella laevis L. aerial parts family lamiaceae (labiatae), supported by phytochemical investigation and molecular docking study

被引：11

作者：

Hamed, Ashraf N. E. ^{[1
]}

Abdelaty, Nousiba A. ^{[1
]}

Attia, Eman Z. ^{[1
]}

Amin, Mohamed N. ^{[2
]}

Ali, Taha F. S. ^{[3
]}

Afifi, Ahmed H. ^{[4
]}

Abdelmohsen, Usama R. ^{[1
,5
]}

Desoukey, Samar Y. ^{[1
]}

机构：

[1] Minia Univ, Fac Pharm, Dept Pharmacognosy, Al Minya, Egypt

[2] Mansoura Univ, Fac Pharm, Dept Biochem, Mansoura, Egypt

[3] Minia Univ, Fac Pharm, Dept Med Chem, Al Minya, Egypt

[4] Natl Res Ctr, Dept Pharmacognosy, Div Pharmaceut Ind, Giza, Dokki, Egypt

[5] Deraya Univ, Fac Pharm, Dept Pharmacognosy, New Minia, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 05期

关键词：

Moluccella laevis; Lamiaceae (Labiatae); cytotoxic; metabolomic; phytochemical; molecular docking;

D O I：

10.1080/14786419.2021.1876046

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The current biologically guided study aimed the in vitro investigation of cytotoxic activity, identification of the phytochemical content of Moluccella laevis L. aerial parts and supporting this activity by a molecular docking study. Aqueous fraction demonstrated the most potent cytotoxic effect against CACO-2 with IC50 = 0.067 +/- 0.01 mu g/mL. Furthermore, EtOAc fraction showed a remarkable cytotoxic activity against MCF-7 cell line with IC50 = 0.35 +/- 0.02 mu g/mL. Consequently, total ethanolic extract (TEE) and its fractions were subjected to LC-HR-ESI-MS metabolic profiling to discover the constituents that possibly underlie their cytotoxicity. Twenty compounds were tentatively identified from metabolic analysis. Furthermore, eight compounds were isolated. In silico docking study revealed that stachydrine is more likely to account for the antiproliferative activity of both EtOAc and aqueous fractions, probably via its moderate inhibition of receptor tyrosine kinases.

引用

页码：1391 / 1395

页数：5

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