Thermosensitive hydrogels synthesized by fast Diels-Alder reaction in water

被引：103

作者：

Wei, Hong-Liang ^{[1
]}

Yang, Zhe ^{[1
]}

Zheng, Li-Mei ^{[1
]}

Shen, Yan-Min ^{[1
]}

机构：

[1] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Peoples R China

来源：

POLYMER | 2009年 / 50卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Diels-Alder hydrogels; Gelation; Water-accelerating effect; CLICK CHEMISTRY; POLYMERIZATION; COPOLYMER; POLYMERS; GELATION;

D O I：

10.1016/j.polymer.2009.04.032

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel thermosensitive hydrogels have been synthesized by aqueous Diels-Alder reaction of poly(N,N-dimethylacrylamide-co-furfuryl methacrylate) and N-[4-(formyl polyethylene glycol ester) bismaleimide. The gelation time was measured by a via] inversion method and the swelling behavior of dried hydrogel was studied by a general gravimetric method. It was found that water can accelerate Diels-Alder reaction while DMF can accelerate retro-Diels-Alder reaction. The gelation time decreases with the increase of temperature. Swelling/shrinking kinetics indicates that the as-prepared hydrogels have high swelling ratio and can respond to temperature. The strategy described here provides several advantages for the hydrogel formation including mild reaction conditions, no initiator or catalyzer, no organic solvent, tunable gelation rate, and thermal reversibility. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2836 / 2840

页数：5

共 33 条

[1] Rheological and Chemical Analysis of Reverse Gelation in a Covalently Cross-Linked Diels-Alder Polymer Network [J].

Adzima, Brian J. ;

Aguirre, H. Alan ;

Kloxin, Christopher J. ;

Scott, Timothy F. ;

Bowman, Christopher N. .

MACROMOLECULES, 2008, 41 (23) :9112-9117

[2] Reversible releasing of arms from star morphology polymers [J].

Aumsuwan, Nattharika ;

Urban, Marek W. .

POLYMER, 2009, 50 (01) :33-36

[3] PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release [J].

Bhattarai, N ;

Ramay, HR ;

Gunn, J ;

Matsen, FA ;

Zhang, MQ .

JOURNAL OF CONTROLLED RELEASE, 2005, 103 (03) :609-624

[4] Preparation and evaluation of thermo-reversible copolymer hydrogels containing chitosan and hyaluronic acid as injectable cell carriers [J].

Chen, Jyh-Ping ;

Cheng, Tai-Hong .

POLYMER, 2009, 50 (01) :107-116

[5] A thermally re-mendable cross-linked polymeric material [J].

Chen, XX ;

Dam, MA ;

Ono, K ;

Mal, A ;

Shen, HB ;

Nutt, SR ;

Sheran, K ;

Wudl, F .

SCIENCE, 2002, 295 (5560) :1698-1702

[6] A NOVEL NONIONIC HYDROGEL FROM 2-METHYL-2-OXAZOLINE .4. REVERSIBLE GELATION OF POLYOXAZOLINE BY MEANS OF DIELS-ALDER REACTION [J].

CHUJO, Y ;

SADA, K ;

SAEGUSA, T .

MACROMOLECULES, 1990, 23 (10) :2636-2641

[7] Controlling dispersion and migration of particulate additives with block copolymers and Diels-Alder chemistry [J].

Costanzo, Philip J. ;

Demaree, J. Derek ;

Beyer, Frederick L. .

LANGMUIR, 2006, 22 (24) :10251-10257

[8] Preparation of 3-arm star polymers (A3) via Diels-Alder click reaction [J].

Dag, Aydan ;

Durmaz, Hakan ;

Hizal, Gurkan ;

Tunca, Umit .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2008, 46 (01) :302-313

[9] pH- and temperature-sensitive multiblock copolymer hydrogels composed of poly(ethylene glycol) and poly(amino urethane) [J].

Dayananda, Kasala ;

He, Chaoliang ;

Park, Dong Kuk ;

Park, Tae Gwan ;

Lee, Doo Sung .

POLYMER, 2008, 49 (23) :4968-4973

[10] Diels-Alder reactions with novel polymeric dienes and dienophiles: Synthesis of reversibly cross-linked elastomers [J].

Gheneim, R ;

Perez-Berumen, C ;

Gandini, A .

MACROMOLECULES, 2002, 35 (19) :7246-7253

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