A practical synthesis of 3,4-diethoxybenzthioamide based on Friedel-Crafts reaction with potassium thiocyanate in methanesulfonic acid

被引：16

作者：

Aki, S ^{[1
]}

Fujioka, T ^{[1
]}

Ishigami, M ^{[1
]}

Minamikawa, J ^{[1
]}

机构：

[1] Otsuka Pharmaceut Co Ltd, Proc Res Lab, Tokushima Factory 2, Kawaguchi, Tokushima 7710182, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(02)00398-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 3,4-diethoxybenzthioamide, the key intermediate for OPC-6535, is achieved by employing Friedel-Crafts reaction of 1,2-diethoxybenzene with potassium thiocyanate in methanesulfonic acid at ambient temperature. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2317 / 2320

页数：4

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