Silyl modification of biologically active compounds. 12. Silyl group as true incentive to antitumour and antibacterial action of choline and colamine analogues

被引：15
作者：
Zablotskaya, Alla
Segal, Izolda
Popelis, Yuris
Lukevics, Edmunds
Baluja, Shipra
Shestakova, Irina
Domracheva, Ilona
机构：
[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia
[2] Saurashtra Univ, Rajkot 360005, Gujarat, India
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2006年 / 20卷 / 11期
关键词：
organosilicon compounds; alkanolamines; drug research; antitumour activity; antimicrobial activity;
D O I：
10.1002/aoc.1133
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A series of triorganylsilyl(beta-dialkylaminoethoxy)silanes was prepared and characterized by elemental analysis, H-1, C-13, Si-29 NMR and mass spectroscopy. Comparative study of Si-29 resonance of newly synthesized compounds showed correlation between its value and substituent nature at the silicon atom, and is shifted upfield for beta-triorganyl(N,N-dialkylaminoethoxy)silanes in comparison with corresponding methiodides, revealing weak N...Si interaction for proper silanes. In vitro antitumour and antimicrobial properties were investigated. The biological activity data exhibited a marked enhancement of inhibitory activity on trialkylsilylation against tumour cell lines and all the test bacterial/fungal strains. Copyright (c) 2006 John Wiley & Sons, Ltd.
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收藏
页码：721 / 728
页数：8
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