Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission

被引：59

作者：

Montanari, Martina ^{[1
,2
]}

Martella, Giuseppina ^{[1
]}

Bonsi, Paola ^{[1
]}

Meringolo, Maria ^{[1
]}

机构：

[1] IRCCS Fdn Santa Lucia, Lab Neurophysiol & Plast, I-00179 Rome, Italy

[2] Univ Tor Vergata, Dept Syst Neurosci, I-00133 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 07期

关键词：

brain development; ASD genes; animal model; signaling; therapy; glutamate receptors; metabolism; gut; MAGNETIC-RESONANCE-SPECTROSCOPY; GAMMA-AMINOBUTYRIC-ACID; FAMILY-BASED ASSOCIATION; LONG-TERM POTENTIATION; ENTERIC NERVOUS-SYSTEM; KNOCKOUT MOUSE MODEL; MESSENGER-RNA LEVELS; PLASMA AMINO-ACIDS; GRM7; GENE; SYNAPTIC PLASTICITY;

D O I：

10.3390/ijms23073861

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Disturbances in the glutamatergic system have been increasingly documented in several neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered theories of ASD are based on evidence from patient samples and postmortem studies, as well as from studies documenting abnormalities in glutamatergic gene expression and metabolic pathways, including changes in the gut microbiota glutamate metabolism in patients with ASD. In addition, preclinical studies on animal models have demonstrated glutamatergic neurotransmission deficits and altered expression of glutamate synaptic proteins. At present, there are no approved glutamatergic drugs for ASD, but several ongoing clinical trials are currently focusing on evaluating in autistic patients glutamatergic pharmaceuticals already approved for other conditions. In this review, we provide an overview of the literature concerning the role of glutamatergic neurotransmission in the pathophysiology of ASD and as a potential target for novel treatments.

引用

页数：32

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