Informed participation in a randomised controlled trial of computed tomography screening for lung cancer

被引:46
作者
van den Bergh, K. A. M. [1 ]
Essink-Bot, M. L. [1 ,3 ]
van Klaveren, R. J. [2 ]
de Koning, H. J. [1 ]
机构
[1] Erasmus MC, Univ Med Ctr Rotterdam, Dept Publ Hlth, NL-3000 CA Rotterdam, Netherlands
[2] Erasmus MC, Univ Med Ctr Rotterdam, Dept Pulmonol, NL-3000 CA Rotterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Social Med, NL-1105 AZ Amsterdam, Netherlands
关键词
Informed decision-making; knowledge; lung neoplasms; mass screening; participation; DECISION-MAKING; CERVICAL-CANCER; PREGNANT-WOMEN; SPIRAL CT; KNOWLEDGE; ATTITUDES; CHOICE; IMPACT; INFORMATION; PART;
D O I
10.1183/09031936.00098908
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
The actual lung cancer (screening) knowledge, attitudes, risk perceptions, reasons to participate in or decline participation, and informed decisions of subjects who decided to or decided not to participate in the Dutch-Belgian randomised controlled trial for lung cancer screening in high-risk subjects (the NELSON trial) were evaluated. A total of 2,500 high-risk subjects were asked to complete a questionnaire 3 weeks after they had received a brochure with information about the trial. Differences in knowledge, attitude and risk perception between participants and nonparticipants were analysed with logistic regression analyses adjusted for sex and smoking status. The questionnaire response of trial participants was 80% (n=889) whereas the response of nonparticipants was low (7%, n=97 and selective. Participants' responses to knowledge items on lung cancer as a disease were on average more often correct (mean +/- SD 68 +/- 17%) than items on lung cancer screening (49 +/- 29%). Participants had adequate knowledge on lung cancer screening (51%) more often than the nonparticipants (38%; p=0.009). Of the decisions regarding participation, 49% were uninformed, mainly due to insufficient knowledge. Most of the participants (99%) and 64% of the nonparticipants had a positive attitude towards lung cancer screening. Additional efforts are required to improve the knowledge and understanding of subjects who are in the process of decision-making regarding participation in a lung cancer screening trial.
引用
收藏
页码:711 / 720
页数:10
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