Comparative study on the chiral separation of phenyl alcohols by capillary electrophoresis and liquid chromatography

被引：18

作者：

Zhang, YP

Lee, KP ^{[1
]}

Kim, SH

Choi, SH

Gopalan, AI

Yuan, ZB

机构：

[1] Kyungpook Natl Univ, Grad Sch, Dept Chem, Taejon 702701, South Korea

[2] Chinese Acad Sci, Grad Sch, Dept Chem, Beijing, Peoples R China

[3] Hannam Univ, Dept Chem, Taejon, South Korea

[4] Alagappa Univ, Dept Ind Chem, Karaikkudi, Tamil Nadu, India

来源：

ELECTROPHORESIS | 2004年 / 25卷 / 16期

关键词：

capillary electrophoresis; enantiomer separation; liquid chromatography; statistical experimental design; sulfated beta-cycloclextrin;

D O I：

10.1002/elps.200405969

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Structurally related phenyl alcohols were separated by capillary electrophoresis and liquid chromatography. A statistical experimental design was used in order to optimize the main electrophoretic parameters such as pH, concentration of selector and separation voltage in capillary electrophoresis (CE). Response surfaces were derived using the mathematical model and used for a selection of the optimal experimental conditions. Concentration of the chiral selector, the distance between the aromatic group and asymmetric center of the analytes, were identified as the factors influencing the complexation, selectivity and resolution. Experiments were also performed by high-performance liquid chromatography (HPLC) and the results of CE and HPLC were compared.

引用

页码：2711 / 2719

页数：9

共 25 条

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2-Z

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