Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques

被引:1
作者
Fernandes, Rosilainy Surubi [1 ]
David, Mariana Rocha [1 ]
Santos De Abreu, Filipe Vieira [1 ]
Ferreira-de-Brito, Anielly [1 ]
Gardinali, Noemi R. [2 ,3 ]
Barbosa Lima, Sheila Maria [3 ]
Ribeiro Andrade, Marcia Cristina [4 ]
Kugelmeier, Tatiana [4 ]
de Oliveira, Jaqueline Mendes [2 ]
Pinto, Marcelo A. [2 ]
Lourenco-de-Oliveira, Ricardo [1 ]
机构
[1] Fiocruz MS, Lab Mosquitos Transmissores Hematozoarios, Inst Oswaldo Cruz, BR-21040900 Rio De Janeiro, Brazil
[2] Fiocruz MS, Lab Desenvolvimento Tecnol Virol, Inst Oswaldo Cruz, BR-21040900 Rio De Janeiro, Brazil
[3] Fiocruz MS, Inst Tecnol Imunobiol Biomanguinhos, Lab Tecnol Imunol, BR-21040900 Rio De Janeiro, Brazil
[4] Fiocruz MS, Inst Ciencia & Tecnol Biomodelos ICTB, Serv Criacao Primatas Nao Humans, BR-21040900 Rio De Janeiro, Brazil
来源
VIRUSES-BASEL | 2020年 / 12卷 / 12期
基金
欧盟地平线“2020”;
关键词
non-human primates; rhesus macaques; Zika; viremia; vectorial capacity; transmission; GUILLAIN-BARRE-SYNDROME; TRANSMISSION; BRAZIL; INFECTION; PROSPECTS; EPIDEMIC; OUTBREAK; INSIGHTS; BIOLOGY; BAHIA;
D O I
10.3390/v12121345
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Despite worldwide efforts to understand the transmission dynamics of Zika virus (ZIKV), scanty evaluation has been made on the vector competence of Aedes aegypti fed directly on viremic human and non-human primates (NHPs). We blood-fed Ae. aegypti from two districts in Rio de Janeiro on six ZIKV infected pregnant rhesus macaques at several time points, half of which were treated with Sofosbuvir (SOF). Mosquitoes were analyzed for vector competence after 3, 7 and 14 days of incubation. Although viremia extended up to eight days post monkey inoculation, only mosquitoes fed on the day of the peak of viremia, recorded on day two, became infected. The influence of SOF treatment could not be assessed because the drug was administered just after mosquito feeding on day two. The global infection, dissemination and transmission rates were quite low (4.09%, 1.91% and 0.54%, respectively); no mosquito was infected when viremia was below 1.26 x 10(5) RNA copies/mL. In conclusion, Ae. aegypti vector competence for ZIKV from macaques is low, likely to be due to low viral load and the short duration of ZIKV viremia in primates suitable for infecting susceptible mosquitoes. If ZIKV infection in human and macaques behaves similarly, transmission of the Zika virus in nature is most strongly affected by vector density.
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页数:12
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共 58 条
  • [1] The tortoise or the hare? Impacts of within-host dynamics on transmission success of arthropod-borne viruses
    Althouse, Benjamin M.
    Hanley, Kathryn A.
    [J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2015, 370 (1675)
  • [2] Malta JMAS, 2017, EPIDEMIOL SERV SAUDE, V26, P9, DOI [10.5123/S1679-49742017000100002, 10.5123/s1679-49742017000100002]
  • [3] [Anonymous], 2018, VIRUSES BASEL, DOI DOI 10.3390/v10110661
  • [4] [Anonymous], 2016, ANTIVIR RES, DOI [DOI 10.1016/j.antiviral.2016.03.010, DOI 10.1016/J.ANTIVIRAL.2016.03.010]
  • [5] Vector Competence: What Has Zika Virus Taught Us?
    Azar, Sasha R.
    Weaver, Scott C.
    [J]. VIRUSES-BASEL, 2019, 11 (09):
  • [6] Detection of yellow fever virus: a comparison of quantitative real-time PCR and plaque assay
    Bae, HG
    Nitsche, A
    Teichmann, A
    Biel, SS
    Niedrig, M
    [J]. JOURNAL OF VIROLOGICAL METHODS, 2003, 110 (02) : 185 - 191
  • [7] BEARCROFT W. G. C., 1956, TRANS ROY SOC TROP MED AND HYG, V50, P442, DOI 10.1016/0035-9203(56)90090-6
  • [8] High susceptibility, viral dynamics and persistence of South American Zika virus in New World monkey species
    Berry, Neil
    Ferguson, Deborah
    Ham, Claire
    Hall, Jo
    Jenkins, Adrian
    Giles, Elaine
    Devshi, Dhruti
    Kempster, Sarah
    Rose, Nicola
    Dowall, Stuart
    Fritzsche, Martin
    Bleazard, Thomas
    Hewson, Roger
    Almond, Neil
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [9] Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies
    Best, Katharine
    Guedj, Jeremie
    Madelain, Vincent
    de Lamballerie, Xavier
    Lim, So-Yon
    Osuna, Christa E.
    Whitney, James B.
    Perelson, Alan S.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (33) : 8847 - 8852
  • [10] Guillain-Barre syndrome associated with Zika virus infection
    Brasil, Patricia
    Sequeira, Patricia Carvalho
    Freitas, Andrea D'Avila
    Zogbi, Heruza Einsfeld
    Calvet, Guilherme Amaral
    de Souza, Rogerio Valls
    Siqueira, Andre Machado
    Lima de Mendonca, Marcos Cesar
    Ribeiro Nogueira, Rita Maria
    Bispo de Filippis, Ana Maria
    Solomon, Tom
    [J]. LANCET, 2016, 387 (10026) : 1482 - 1482