Current and future technological advances in transdermal gene delivery

被引：56

作者：

Chen, Xianfeng ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Bioengn, Sch Engn, Kings Bldg,Mayfield Rd, Edinburgh EH9 3JL, Midlothian, Scotland

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2018年 / 127卷

关键词：

Skin delivery; Transdermal delivery; Physical approaches; Chemical approaches; Gene therapy; Skin vaccination; DNA VACCINE DELIVERY; MICROPROJECTION ARRAY PATCHES; CELL-PENETRATING PEPTIDES; DIAMOND-NANONEEDLE-ARRAY; TOPICAL SIRNA DELIVERY; PROOF-OF-CONCEPT; IN-VIVO DNA; DRUG-DELIVERY; PLASMID DNA; SKIN ELECTROPORATION;

D O I：

10.1016/j.addr.2017.12.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transdermal gene delivery holds significant advantages as it is able to minimize the problems of systemic administration such as enzymatic degradation, systemic toxicity, and poor delivery to target tissues. This technology has the potential to transform the treatment and prevention of a range of diseases. However, the skin poses a great barrier for gene delivery because of the "bricks-and-mortar" structure of the stratum corneum and the tight junctions between keratinocytes in the epidermis. This review systematically summarizes the typical physical and chemical approaches to overcome these barriers and facilitate gene delivery via skin for applications in vaccination, wound healing, skin cancers and skin diseases. Next, the advantages and disadvantages of different approaches are discussed and the insights for future development are provided. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：85 / 105

页数：21

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