Current and future technological advances in transdermal gene delivery

被引：56
作者：
Chen, Xianfeng [1 ]
机构：
[1] Univ Edinburgh, Inst Bioengn, Sch Engn, Kings Bldg,Mayfield Rd, Edinburgh EH9 3JL, Midlothian, Scotland
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2018年 / 127卷
关键词：
Skin delivery; Transdermal delivery; Physical approaches; Chemical approaches; Gene therapy; Skin vaccination; DNA VACCINE DELIVERY; MICROPROJECTION ARRAY PATCHES; CELL-PENETRATING PEPTIDES; DIAMOND-NANONEEDLE-ARRAY; TOPICAL SIRNA DELIVERY; PROOF-OF-CONCEPT; IN-VIVO DNA; DRUG-DELIVERY; PLASMID DNA; SKIN ELECTROPORATION;
D O I：
10.1016/j.addr.2017.12.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Transdermal gene delivery holds significant advantages as it is able to minimize the problems of systemic administration such as enzymatic degradation, systemic toxicity, and poor delivery to target tissues. This technology has the potential to transform the treatment and prevention of a range of diseases. However, the skin poses a great barrier for gene delivery because of the "bricks-and-mortar" structure of the stratum corneum and the tight junctions between keratinocytes in the epidermis. This review systematically summarizes the typical physical and chemical approaches to overcome these barriers and facilitate gene delivery via skin for applications in vaccination, wound healing, skin cancers and skin diseases. Next, the advantages and disadvantages of different approaches are discussed and the insights for future development are provided. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：85 / 105
页数：21
相关论文
共 193 条
[1]   Gene therapies for inherited skin disorders [J].
Abdul-Wahab, Alya ;
Qasim, Waseem ;
McGrath, John A. .
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 2014, 33 (02) :83-90
[2]   Potential use of iontophoresis for transdermal delivery of NF-κB decoy oligonucleotides [J].
Abu Hashim, Irhan Ibrahim ;
Motoyama, Keiichi ;
Abd-ElGawad, Abd-ElGawad Helmy ;
El-Shabouri, Mohamed H. ;
Borg, Thanaa Mohamed ;
Arima, Hidetoshi .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 393 (1-2) :127-134
[3]   Assessing the Potential Cost-Effectiveness of Microneedle Patches in Childhood Measles Vaccination Programs: The Case for Further Research and Development [J].
Adhikari B.B. ;
Goodson J.L. ;
Chu S.Y. ;
Rota P.A. ;
Meltzer M.I. .
Drugs in R&D, 2016, 16 (4) :327-338
[4]   Progress in Topical siRNA Delivery Approaches for Skin Disorders [J].
Aldawsari, Mohammed ;
Chougule, Mahavir B. ;
Babu, R. Jayachandra .
CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (31) :4594-4605
[5]   DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles [J].
Ali, Ahlam A. ;
McCrudden, Cian M. ;
McCaffrey, Joanne ;
McBride, John W. ;
Cole, Grace ;
Dunne, Nicholas J. ;
Robson, Tracy ;
Kissenpfennig, Adrien ;
Donnelly, Ryan F. ;
McCarthy, Helen O. .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2017, 13 (03) :921-932
[6]   Risk assessment in skin gene therapy: viral-cellular fusion transcripts generated by proviral transcriptional read-through in keratinocytes transduced with self-inactivating lentiviral vectors [J].
Almarza, D. ;
Bussadori, G. ;
Navarro, M. ;
Mavilio, F. ;
Larcher, F. ;
Murillas, R. .
GENE THERAPY, 2011, 18 (07) :674-681
[7]   DNA Nanotechnology for Precise Control over Drug Delivery and Gene Therapy [J].
Angell, Chava ;
Xie, Sibai ;
Zhang, Liangfang ;
Chen, Yi .
SMALL, 2016, 12 (09) :1117-1132
[8]   Rabies vaccination in dogs using a dissolving microneedle patch [J].
Arya, Jaya M. ;
Dewitt, Kristopher ;
Scott-Garrard, Maya ;
Chiang, Yu-Wei ;
Prausnitz, Mark R. .
JOURNAL OF CONTROLLED RELEASE, 2016, 239 :19-26
[9]   Transdermal delivery from liposomal formulations - Evolution of the technology over the last three decades [J].
Ashtikar, Mukul ;
Nagarsekar, Kalpa ;
Fahr, Alfred .
JOURNAL OF CONTROLLED RELEASE, 2016, 242 :126-140
[10]   Prevention of distal flap necrosis in a rat random skin flap model by gene electrotransfer delivering VEGF165 plasmid [J].
Basu, Gaurav ;
Downey, Harre ;
Guo, Siqi ;
Israel, Annelise ;
Asmar, Anthony ;
Hargrave, Barbara ;
Heller, Richard .
JOURNAL OF GENE MEDICINE, 2014, 16 (3-4) :55-65
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