A Chemical Approach to Immunoprotein Engineering: Chemoselective Functionalization of Thioester Proteins in Their Native State

被引：5

作者：

Cole, Michael A. ^{[1
]}

Tully, Sarah E. ^{[1
,3
,4
]}

Dodds, Alister W. ^{[2
]}

Arnold, James N. ^{[1
]}

Boldt, Grant E. ^{[1
]}

Sim, Robert B. ^{[2
]}

Offer, John ^{[1
]}

Wentworth, Paul, Jr. ^{[1
,3
,4
]}

机构：

[1] Univ Oxford, Dept Biochem, Scripps Oxford Lab, Oxford OX1 3QU, England

[2] Univ Oxford, Dept Biochem, MRC Immunochem Unit, Oxford OX1 3QU, England

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 08期

基金：

英国医学研究理事会;

关键词：

activity-based protein profiling; hydrazides; peptides; proteins; thioesters; ALTERNATIVE COMPLEMENT PATHWAY; CONFORMATIONAL-CHANGES; PUTATIVE THIOESTER; COMPONENT C3; C-3; BINDING; ALPHA-2-MACROGLOBULIN; ACQUISITION; CONVERTASE; ACTIVATION;

D O I：

10.1002/cbic.200900168

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：1340 / 1343

页数：4

共 3 条

[1] An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation
Blanco-Canosa, Juan B.
Dawson, Philip E.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (36) : 6851 - 6855
[2] Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology
Adusumalli, Srinivasa Rao
Rawale, Tdattatraya Gautam
Singh, Usha
Tripathi, Prabhanshu
Paul, Rajesh
Kalra, Neetu
Mishra, Ram Kumar
Shukla, Sanjeev
Rai, Vishal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (44) : 15114 - 15123
[3] Post-Assembly Functionalization of Supramolecular Nanostructures with Bioactive Peptides and Fluorescent Proteins by Native Chemical Ligation
Khan, Saahir
Sur, Shantanu
Dankers, Patricia Y. W.
da Silva, Ricardo M. P.
Boekhoven, Job
Poor, Taylor A.
Stupp, Samuel I.
BIOCONJUGATE CHEMISTRY, 2014, 25 (04) : 707 - 717

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