共 41 条
Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background
被引:86
作者:

Ding, Qi
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h-index: 0
机构:
Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA

Sethna, Ferzin
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h-index: 0
机构:
Michigan State Univ, Genet Program, E Lansing, MI 48824 USA Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA

Wang, Hongbing
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h-index: 0
机构:
Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA
Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA
机构:
[1] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA
[2] Michigan State Univ, Genet Program, E Lansing, MI 48824 USA
[3] Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA
关键词:
Fragile X syndrome;
Fmr1 knockout mice;
Genetic background;
Gender;
Behavioral phenotypes;
FRAGILE-X-SYNDROME;
SYNDROME MOUSE MODEL;
MENTAL-RETARDATION;
SYNAPTIC PLASTICITY;
GENETIC REDUCTION;
ADENYLYL-CYCLASE;
STARTLE RESPONSE;
MESSENGER-RNAS;
PROTEIN;
MEMORY;
D O I:
10.1016/j.bbr.2014.05.046
中图分类号:
B84 [心理学];
C [社会科学总论];
Q98 [人类学];
学科分类号:
03 ;
0303 ;
030303 ;
04 ;
0402 ;
摘要:
Fragile X syndrome (FXS) is a monogenic disease caused by mutations in the FMR1 gene. The Fmr1 knock-out (KO) mice show many aspects of FXS-related phenotypes, and have been used as a major pre-clinical model for FXS. Although FXS occurs in both male and female patients, most studies on the mouse model use male animals. Few studies test whether gender affects the face validity of the mouse model. Here, we examined multiple behavioral phenotypes with male hemizygous and female homozygous Fmr1 KO mice on C57BL/6 background. For each behavioral paradigm, we examined multiple cohorts from different litters. We found that both male and female Fmr1 KO mice displayed significant audiogenic seizures, hyperactivity in the open field test, deficits in passive avoidance and contextual fear memory, and significant enhancement of PPI at low stimulus intensity. Male and female Fmr1 KO mice also showed more transitional movement between the lit and dark chambers in the light-dark tests. The lack of gender effects suggests that the Fmr1 KO mouse is a reasonable tool to test the efficacy of potential FXS therapies. (C) 2014 Elsevier B.V. All rights reserved.
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页码:72 / 78
页数:7
相关论文
共 41 条
[1]
FMRP targets distinct mRNA sequence elements to regulate protein expression
[J].
Ascano, Manuel, Jr.
;
Mukherjee, Neelanjan
;
Bandaru, Pradeep
;
Miller, Jason B.
;
Nusbaum, Jeffrey D.
;
Corcoran, David L.
;
Langlois, Christine
;
Munschauer, Mathias
;
Dewell, Scott
;
Hafner, Markus
;
Williams, Zev
;
Ohler, Uwe
;
Tuschl, Thomas
.
NATURE,
2012, 492 (7429)
:382-+

Ascano, Manuel, Jr.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Mukherjee, Neelanjan
论文数: 0 引用数: 0
h-index: 0
机构:
Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Bandaru, Pradeep
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Miller, Jason B.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Nusbaum, Jeffrey D.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Corcoran, David L.
论文数: 0 引用数: 0
h-index: 0
机构:
Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Langlois, Christine
论文数: 0 引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Program Early & Recurrent Pregnancy Loss, Bronx, NY 10461 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Munschauer, Mathias
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Dewell, Scott
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Genom Resource Ctr, New York, NY 10065 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Hafner, Markus
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

论文数: 引用数:
h-index:
机构:

Ohler, Uwe
论文数: 0 引用数: 0
h-index: 0
机构:
Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA

Tuschl, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA Rockefeller Univ, Howard Hughes Med Inst, Lab RNA Mol Biol, New York, NY 10065 USA
[2]
Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics
[J].
Bagni, Claudia
;
Tassone, Flora
;
Neri, Giovanni
;
Hagerman, Randi
.
JOURNAL OF CLINICAL INVESTIGATION,
2012, 122 (12)
:4314-4322

Bagni, Claudia
论文数: 0 引用数: 0
h-index: 0
机构:
Catholic Univ Louvain, VIB Ctr Biol Dis, Fac Med, B-3000 Louvain, Belgium
Katholieke Univ Leuven, Ctr Human Genet, Louvain, Belgium
Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy Catholic Univ Louvain, VIB Ctr Biol Dis, Fac Med, B-3000 Louvain, Belgium

论文数: 引用数:
h-index:
机构:

Neri, Giovanni
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cattolica Sacro Cuore, Inst Med Genet, Rome, Italy Catholic Univ Louvain, VIB Ctr Biol Dis, Fac Med, B-3000 Louvain, Belgium

Hagerman, Randi
论文数: 0 引用数: 0
h-index: 0
机构:
UCD, Med Ctr, UC Davis MIND Inst, Sacramento, CA USA
UCD, Davis Med Ctr, Dept Pediat, Sacramento, CA USA Catholic Univ Louvain, VIB Ctr Biol Dis, Fac Med, B-3000 Louvain, Belgium
[3]
Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments
[J].
Baker, K. B.
;
Wray, S. P.
;
Ritter, R.
;
Mason, S.
;
Lanthorn, T. H.
;
Savelieva, K. V.
.
GENES BRAIN AND BEHAVIOR,
2010, 9 (06)
:562-574

Baker, K. B.
论文数: 0 引用数: 0
h-index: 0
机构:
Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA

Wray, S. P.
论文数: 0 引用数: 0
h-index: 0
机构:
Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA

Ritter, R.
论文数: 0 引用数: 0
h-index: 0
机构:
Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA

Mason, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA

Lanthorn, T. H.
论文数: 0 引用数: 0
h-index: 0
机构:
Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA

Savelieva, K. V.
论文数: 0 引用数: 0
h-index: 0
机构:
Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA Lexicon Pharmaceut Inc, Neurosci Res, The Woodlands, TX 77381 USA
[4]
Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice
[J].
Bhattacharya, Aditi
;
Kaphzan, Hanoch
;
Alvarez-Dieppa, Amanda C.
;
Murphy, Jaclyn P.
;
Pierre, Philippe
;
Klann, Eric
.
NEURON,
2012, 76 (02)
:325-337

Bhattacharya, Aditi
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Ctr Neural Sci, New York, NY 10003 USA NYU, Ctr Neural Sci, New York, NY 10003 USA

Kaphzan, Hanoch
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Ctr Neural Sci, New York, NY 10003 USA NYU, Ctr Neural Sci, New York, NY 10003 USA

Alvarez-Dieppa, Amanda C.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Ctr Neural Sci, New York, NY 10003 USA NYU, Ctr Neural Sci, New York, NY 10003 USA

Murphy, Jaclyn P.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Ctr Neural Sci, New York, NY 10003 USA NYU, Ctr Neural Sci, New York, NY 10003 USA

Pierre, Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Mediterranee, CNRS, INSERM, Ctr Immunol Marseille Luminy, F-13288 Marseille 09, France
INSERM, U1104, F-13288 Marseille, France
CNRS, UMR 7280, F-13288 Marseille, France NYU, Ctr Neural Sci, New York, NY 10003 USA

Klann, Eric
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Ctr Neural Sci, New York, NY 10003 USA NYU, Ctr Neural Sci, New York, NY 10003 USA
[5]
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
[J].
Brown, V
;
Jin, P
;
Ceman, S
;
Darnell, JC
;
O'Donnell, WT
;
Tenenbaum, SA
;
Jin, XK
;
Feng, Y
;
Wilkinson, KD
;
Keene, JD
;
Darnell, RB
;
Warren, ST
.
CELL,
2001, 107 (04)
:477-487

Brown, V
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Jin, P
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Ceman, S
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Darnell, JC
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

O'Donnell, WT
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Tenenbaum, SA
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Jin, XK
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Feng, Y
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Wilkinson, KD
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Keene, JD
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Darnell, RB
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA

Warren, ST
论文数: 0 引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA Emory Univ, Sch Med, Howard Hughes Med Inst, Dept Human Genet,Dept Pediat, Atlanta, GA 30322 USA
[6]
FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
[J].
Darnell, Jennifer C.
;
Van Driesche, Sarah J.
;
Zhang, Chaolin
;
Hung, Ka Ying Sharon
;
Mele, Aldo
;
Fraser, Claire E.
;
Stone, Elizabeth F.
;
Chen, Cynthia
;
Fak, John J.
;
Chi, Sung Wook
;
Licatalosi, Donny D.
;
Richter, Joel D.
;
Darnell, Robert B.
.
CELL,
2011, 146 (02)
:247-261

Darnell, Jennifer C.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Van Driesche, Sarah J.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Zhang, Chaolin
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Hung, Ka Ying Sharon
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Mele, Aldo
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Fraser, Claire E.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Stone, Elizabeth F.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Chen, Cynthia
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Fak, John J.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Chi, Sung Wook
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Licatalosi, Donny D.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Richter, Joel D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA

Darnell, Robert B.
论文数: 0 引用数: 0
h-index: 0
机构:
Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA
Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10065 USA
[7]
Fmr1 knockout mouse has a distinctive strain-specific learning impairment
[J].
Dobkin, C
;
Rabe, A
;
Dumas, R
;
El Idrissi, A
;
Haubenstock, H
;
Brown, WT
.
NEUROSCIENCE,
2000, 100 (02)
:423-429

Dobkin, C
论文数: 0 引用数: 0
h-index: 0
机构: New York State Inst Basic Res Dev Disabil, Dept Genet, Staten Isl, NY 10314 USA

Rabe, A
论文数: 0 引用数: 0
h-index: 0
机构: New York State Inst Basic Res Dev Disabil, Dept Genet, Staten Isl, NY 10314 USA

Dumas, R
论文数: 0 引用数: 0
h-index: 0
机构: New York State Inst Basic Res Dev Disabil, Dept Genet, Staten Isl, NY 10314 USA

El Idrissi, A
论文数: 0 引用数: 0
h-index: 0
机构: New York State Inst Basic Res Dev Disabil, Dept Genet, Staten Isl, NY 10314 USA

Haubenstock, H
论文数: 0 引用数: 0
h-index: 0
机构: New York State Inst Basic Res Dev Disabil, Dept Genet, Staten Isl, NY 10314 USA

Brown, WT
论文数: 0 引用数: 0
h-index: 0
机构: New York State Inst Basic Res Dev Disabil, Dept Genet, Staten Isl, NY 10314 USA
[8]
Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
[J].
Edbauer, Dieter
;
Neilson, Joel R.
;
Foster, Kelly A.
;
Wang, Chi-Fong
;
Seeburg, Daniel P.
;
Batterton, Matthew N.
;
Tada, Tomoko
;
Dolan, Bridget M.
;
Sharp, Phillip A.
;
Sheng, Morgan
.
NEURON,
2010, 65 (03)
:373-384

Edbauer, Dieter
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02319 USA
MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA

Neilson, Joel R.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA

Foster, Kelly A.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02319 USA
MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA

Wang, Chi-Fong
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02319 USA
MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA

Seeburg, Daniel P.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02319 USA
MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA

Batterton, Matthew N.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02319 USA
MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA

Tada, Tomoko
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02319 USA
MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA

Dolan, Bridget M.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02319 USA
MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA

Sharp, Phillip A.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02319 USA
MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA

Sheng, Morgan
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02319 USA
MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02319 USA MIT, Dept Biol, Cambridge, MA 02319 USA
[9]
Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice
[J].
Frankland, PW
;
Wang, Y
;
Rosner, B
;
Shimizu, T
;
Balleine, BW
;
Dykens, EM
;
Ornitz, EM
;
Silva, AJ
.
MOLECULAR PSYCHIATRY,
2004, 9 (04)
:417-425

Frankland, PW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA

Wang, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA

Rosner, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA

Shimizu, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA

Balleine, BW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA

Dykens, EM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA

Ornitz, EM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA

Silva, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA
[10]
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
[J].
Goebel-Goody, S. M.
;
Wilson-Wallis, E. D.
;
Royston, S.
;
Tagliatela, S. M.
;
Naegele, J. R.
;
Lombroso, P. J.
.
GENES BRAIN AND BEHAVIOR,
2012, 11 (05)
:586-600

Goebel-Goody, S. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06519 USA Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06519 USA

Wilson-Wallis, E. D.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06519 USA Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06519 USA

Royston, S.
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Wesleyan Univ, Dept Biol, Middletown, CT 06459 USA
Wesleyan Univ, Neurosci & Behav Program, Middletown, CT USA Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06519 USA

Tagliatela, S. M.
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Wesleyan Univ, Dept Biol, Middletown, CT 06459 USA
Wesleyan Univ, Neurosci & Behav Program, Middletown, CT USA Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06519 USA

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Lombroso, P. J.
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Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06519 USA Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06519 USA