Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members

被引：24

作者：

Bienstock, Rachelle J. ^{[1
]}

Beard, William A. ^{[1
]}

Wilson, Samuel H. ^{[1
]}

机构：

[1] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

DNA REPAIR | 2014年 / 22卷

基金：

美国国家卫生研究院;

关键词：

DNA polymerase; Evolution; Genomics; Phylogenetic; Structure-function; X-family; SITE-DIRECTED MUTAGENESIS; MULTIPLE SEQUENCE ALIGNMENT; THERMUS-THERMOPHILUS HB8; AMINO-ACID SUBSTITUTION; STATE KINETIC ANALYSES; ACTIVE-SITE; DEINOCOCCUS-RADIODURANS; SUBSTRATE-SPECIFICITY; NUCLEOTIDYL TRANSFER; EXONUCLEASE ACTIVITY;

D O I：

10.1016/j.dnarep.2014.07.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mammalian DNA polymerase (pol) beta is the founding member of a large group of DNA polymerases now termed the X-family. DNA polymerase beta has been kinetically, structurally, and biologically well characterized and can serve as a phylogenetic reference. Accordingly, we have performed a phylogenetic analysis to understand the relationship between pol beta and other members of the X-family of DNA polymerases. The bacterial X-family DNA polymerases, Saccharomyces cerevisiae pol IV, and four mammalian X-family polymerases appear to be directly related. These enzymes originated from an ancient common ancestor characterized in two Bacillus species. Understanding distinct functions for each of the X-family polymerases, evolving from a common bacterial ancestor is of significant interest in light of the specialized roles of these enzymes in DNA metabolism. Published by Elsevier B.V.

引用

页码：77 / 88

页数：12

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