Foxp3+ regulatory T cells in antiretroviral-naive HIV patients

被引：54

作者：

Montes, Martin ^{[1
]}

Lewis, Dorothy E.

Sanchez, Cesar

Lopez de Castilla, Diego

Graviss, Edward A.

Seas, Carlos

Gotuzzo, Eduardo

White, A. Clinton, Jr.

机构：

[1] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Immunol, Houston, TX USA

[3] Baylor Coll Med, Dept Pathol, Houston, TX USA

[4] Univ Peruana Cayetano Heredia, Inst Med Trop Alexander Von Humboldt, Lima, Peru

来源：

AIDS | 2006年 / 20卷 / 12期

关键词：

D O I：

10.1097/01.aids.0000238415.98194.38

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We characterized regulatory T cells from antire-troviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/mu l. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.

引用

收藏

页码：1669 / 1671

页数：3

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