Genome structure and dynamics of the yeast pathogen Candida glabrata

被引：42

作者：

Ahmad, Khadija M. ^{[1
]}

Kokosar, Janez ^{[1
]}

Guo, Xiaoxian ^{[2
]}

Gu, Zhenglong ^{[2
]}

Ishchuk, Olena P. ^{[1
]}

Piskur, Jure ^{[1
]}

机构：

[1] Lund Univ, Dept Biol, SE-22362 Lund, Sweden

[2] Cornell Univ, Div Nutr Sci, Cornell Ctr Computat & Populat Genom, Ithaca, NY 14853 USA

来源：

FEMS YEAST RESEARCH | 2014年 / 14卷 / 04期

基金：

瑞典研究理事会;

关键词：

pathogenic yeast; Candida; virulence genes; chromosome polymorphism; genome rearrangements; BIOFILM FORMATION; EVOLUTION; MEGASATELLITES; SACCHAROMYCES; EPIDEMIOLOGY; VIRULENCE; GENES; MINISATELLITES; SUSCEPTIBILITY; CHROMOSOMES;

D O I：

10.1111/1567-1364.12145

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The yeast pathogen Candida glabrata is the second most frequent cause of Candida infections. However, from the phylogenetic point of view, C.glabrata is much closer to Saccharomyces cerevisiae than to Candida albicans. Apparently, this yeast has relatively recently changed its life style and become a successful opportunistic pathogen. Recently, several C.glabrata sister species, among them clinical and environmental isolates, have had their genomes characterized. Also, hundreds of C.glabrata clinical isolates have been characterized for their genomes. These isolates display enormous genomic plasticity. The number and size of chromosomes vary drastically, as well as intra- and interchromosomal segmental duplications occur frequently. The observed genome alterations could affect phenotypic properties and thus help to adapt to the highly variable and harsh habitats this yeast finds in different human patients and their tissues. Further genome sequencing of pathogenic isolates will provide a valuable tool to understand the mechanisms behind genome dynamics and help to elucidate the genes contributing to the virulence potential.

引用

页码：529 / 535

页数：7

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