Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanoflakes for highly efficient photodynamic therapy in vivo

被引：29
作者：
Yan, Li [1 ,2 ,3 ]
Wang, Zhigang [4 ]
Chen, Xianfeng [5 ]
Gou, Xiao-Jun [1 ]
Zhang, Zhenyu [2 ,3 ]
Zhu, Xiaoyue [2 ,3 ]
Lan, Minhuan [2 ,3 ]
Chen, Wei [2 ,3 ]
Zhu, Guangyu [4 ]
Zhang, Wenjun [2 ,3 ]
机构：
[1] Chengdu Univ, SIIA, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu, Sichuan, Peoples R China
[2] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong, Hong Kong, Peoples R China
[3] City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong, Hong Kong, Peoples R China
[4] City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China
[5] Univ Edinburgh, Sch Engn, Inst Bioengn, Kings Bldg,Mayfield Rd, Edinburgh EH9 3JL, Midlothian, Scotland
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 15期
基金：
中国国家自然科学基金;
关键词：
SYNERGISTIC CANCER-THERAPY; CORE-SHELL NANOPARTICLES; TARGETED DRUG-DELIVERY; COMBINATION THERAPY; NANOCOMPOSITES; FLUORESCENCE; CISPLATIN; DIAGNOSIS; FRAMEWORK; VEHICLES;
D O I：
10.1039/c6cc09510k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In using nanomaterials for advanced photodynamic therapy, it is important to improve surface modification to increase stability, minimize non-specific loss of drugs in blood circulation, enhance the photostability of photosensitizers, and achieve highly efficient intracellular uptake. In this report, we for the first time covalently conjugate photosensitizer Chlorin e6 (Ce6) to polyethylene glycol modified layered double hydroxides and produce hybrid nanoflakes. These nanoflakes display many superior characteristics and lead to excellent in vivo photodynamic therapeutic efficiency and safety profiles.
引用
收藏
页码：2339 / 2342
页数：4
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