Poly (ADP-ribose) polymerase inhibitor: an evolving paradigm in the treatment of prostate cancer

被引：12

作者：

Zhang, Jingsong ^{[1
,2
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Genitourinary Oncol, Tampa, FL 33612 USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Imaging & Metab, Tampa, FL USA

来源：

ASIAN JOURNAL OF ANDROLOGY | 2014年 / 16卷 / 03期

基金：

美国国家卫生研究院;

关键词：

biomarker; PARP inhibitor; prostate cancer; therapy; STRAND BREAK REPAIR; POLY(ADP-RIBOSE) POLYMERASE; HOMOLOGOUS RECOMBINATION; RAD51; OVEREXPRESSION; GENETIC INSTABILITY; INCREASED SURVIVAL; DNA-DAMAGE; HYPOXIA; TEMOZOLOMIDE; ABIRATERONE;

D O I：

10.4103/1008-682X.123684

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Recent phase I studies have reported single-agent activities of poly (ADP-ribose) polymerase (PARP) inhibitor in sporadic and in BRCA-mutant prostate cancers. Two of the most common genetic alterations in prostate cancer, ETS gene rearrangement and loss of PTEN, have been linked to increased sensitivity to PARP inhibitor in preclinical models. Emerging evidence also suggests that PARP1 plays an important role in mediating the transcriptional activities of androgen receptor (AR) and ETS gene rearrangement. In this article, the preclinical work and early-phase clinical trials in developing PARP inhibitor-based therapy as a new treatment paradigm for metastatic prostate cancer are reviewed.

引用

页码：401 / 406

页数：6

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